Tamoxifen citrate (TMC) as a breast cancer drug has side effects at certain doses; hence a drug delivery system is needed. Zirconium-based metal-organic framework with benzene-1,3,5-tricarboxylic acid linkers (MOF-808) impregnated with silver nanoparticles (AgNPs) can form AgNPs@MOF-808 nanocomposites which is a potential candidate to be the drug delivery system. By carried out the synthesis using the solvothermal method, MOF-808 impregnated with AgNPs is having various topolog rather than MOF-808 without the impregnation. MOF-808 (72h) generated the highest crystallinity with the particle size of nano-MOF scale, ranging from ±77-277 nm. MOF-808 was then used as a template for the impregnation of Ag+ into AgNPs with various concentrations of AgNO3 (0.01; 0.05; 0.2; and 0.4 mmol) using DMF as a mild reductant. AgNPs@MOF-808 (0.4) produced several AgNPs at most which were scattered in the MOF pores, with ±5 nm AgNPs nanospherical size and ±130nm of octahedral MOF. The synthesized products were characterized using FT-IR, XRD, SEM-EDX, UV-Vis, and TEM. The anticancer drug delivery system was investigated through in vitro. MOF-808 and AgNPs@MOF-808 had a drug loading efficacy of 55.25% and 44.94% after 72 hours, respectively. Drug release efficacy of MOF-808-TMC reached 73.5% while AgNPs@MOF-808-TMC reached 77.1% on dialysis for 36 hours.