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256673

Evaluation of urinary C-terminal cross-linked telopeptides of type II collagen CTX-II as a biomarker for early diagnosis of osteoarthritis in comparison to routine diagnostic meth

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Last updated: 01 Jan 2025

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Abstract

Background: Work-related musculoskeletal disorders (WRMSDs) are serious occupational health problems among workers worldwide. Aim of the study: evaluate urinary C‐ terminal telopeptide of collagen type II (CTX-II) as a biomarker for early diagnosis of osteoarthritis and compare results with those obtained by the routinely used methods. Subjects and methods: One hundred and eighty workers from the outpatient clinics of rehabilitation center in Cairo performing physically demanding and office jobs. One hundred and twenty three workers diagnosed with knee OA (Group I) and 57 workers were healthy (Group II). Clinical examination, X-rays and questionnaire were done. Erythrocyte sedimentation rate, high sensitive C reactive protein and human CTX-II were measured. Results: No statistical significant difference between CTX-II in osteoarthritis workers and age, residence, smoking status and sport practice. Marked increase of urinary CTX-II level was found in osteoarthritis workers compared to healthy group. A high significance difference between CTX-II level and Western Ontario and Mc master Universities Arthritis Index (WOMAC) index scores in osteoarthritis workers, in addition high levels were found among grade 4 osteoarthritis. Mean urinary level of CTX-II in osteoarthritis workers increased with increased work duration and total working hours. Conclusion: Urinary CTX-II can predict clinical diagnostic criteria and x-ray progression in osteoarthritis, so it can be used as a tool for diagnosis of knee OA.

DOI

10.21608/ejchem.2022.147871.6424

Keywords

Key words: WRMSD, osteoarthritis, WOMAC index scores, X- ray, urinary CTX-II

Authors

First Name

Lamia

Last Name

Ellaithy

MiddleName

Samir

Affiliation

Researcher environmental & Occupational Medicine Department, Environment and Climate Change Research Institute, National Research Centre, Egypt.

Email

lamiaasameer@gmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Moselhi

MiddleName

-

Affiliation

Professor of Occupational Health and Industrial Medicine, Department of Occupational Health and Industrial Medicine, High Institute of Public Health, Alexandria University, Egypt.

Email

hiph.drmmoselhi@alexu.edu.eg

City

-

Orcid

-

First Name

Ragaa

Last Name

El Gazzar

MiddleName

-

Affiliation

Professor of Occupational Hygiene (Biological Monitoring), Department of Occupational Health and Industrial Medicine High Institute of Public Health, Alexandria University, Egypt.

Email

ragaaelgazzar@hotmail.com

City

-

Orcid

-

First Name

Nagat

Last Name

Amer

MiddleName

M.

Affiliation

Professor of Public Health. Environmental & Occupational Medicine Department- Division of Environmental Research- National Research Centre, Giza, Egypt

Email

drnagatamer@yahoo.com

City

-

Orcid

-

First Name

Taher

Last Name

Mansour

MiddleName

Amin

Affiliation

Assistant Professor of Occupational Health and Industrial Medicine, Department of Occupational Health and Industrial Medicine, High Institute of Public Health, Alexandria University, Egypt.

Email

tamansour@yahoo.com

City

-

Orcid

-

First Name

Mona

Last Name

Taha

MiddleName

-

Affiliation

Environmental and Occupational Medicine department, National Research Center

Email

monataha45@yahoo.com

City

-

Orcid

-

First Name

Weam

Last Name

Shaheen

MiddleName

-

Affiliation

Professor of environmental health, Environmental and Occupational medicine department, NRC

Email

weamshaheen@gmail.com

City

-

Orcid

-

First Name

Asmaa Mahmoud

Last Name

Mohammed

MiddleName

-

Affiliation

Department of Environmental and Occupational medicine, National Research Centre, Egypt.

Email

asmamahdy@yahoo.com

City

-

Orcid

0000-0002-2534-2256

Volume

65

Article Issue

13

Related Issue

37459

Issue Date

2022-12-01

Receive Date

2022-07-02

Publish Date

2022-12-01

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_256673.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=256673

Order

256,673

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Evaluation of urinary C-terminal cross-linked telopeptides of type II collagen CTX-II as a biomarker for early diagnosis of osteoarthritis in comparison to routine diagnostic methods

Details

Type

Article

Created At

22 Jan 2023