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256568

Curcumin Ameliorates Acrylamide Induced Ovarian Toxicity in Albino Female Rats: A Biochemical and Histological Study

Article

Last updated: 22 Jan 2023

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Tags

Biochemistry

Abstract

Acrylamide (AA), an industrial compound, causes reproductive toxicity in female rats due to oxidative stress. In the present study, we investigated the protective effects of Curcumin (Cur) against acrylamide-induced ovarian toxicity in female rats. The animals utilized in this study were divided into 4 groups: GI- Control group received a daily oral administration of 0.5ml DMSO (5%) saline(9%), GII- Acrylamide (AA) group received acrylamide (20 mg/kg b.w.) for 21days, GIII- Acrylamide + Curcumin (AA + Cur) group treated with Curcumin (100 mg/kg b.w.) after acrylamide intoxication for 21 days, GIV- Curcumin (Cur) group that received only Curcumin (100 mg/kg b.w.). In our study, we observed acrylamide intoxication to be associated with a significant (P<0.05) increase in the serum levels of estradiol, luteinizing hormone (LH), testosterone (T), and tumor marker CA125 and CEA. The mean values of serum progesterone (P4), follicle-stimulating hormone (FSH), and total antioxidant capacity (TAC) significantly decreased in the AA treated group as compared to the control. Histological investigations revealed that AA treatment results in an apparent regression of ovarian follicles, cyst formation, and corpus luteum degeneration. Treatment with curcumin restored altered ovarian histology and serological indices concomitantly towards normal

DOI

10.21608/ejchem.2022.139554.6136

Keywords

Keywords: Reproductive, female toxicity, acrylamide, Curcumin

Authors

First Name

Nagwa M

Last Name

Elsawi

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524, Egypt.

Email

hamde_r2001@yahoo.com

City

-

Orcid

-

First Name

Shymaa A. Th.

Last Name

Abo Kresha

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524, Egypt.

Email

-

City

-

Orcid

-

First Name

Mounir A. A.

Last Name

Mohamed

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524, Egypt.

Email

-

City

-

Orcid

-

First Name

Ahmed

Last Name

Khorshed

MiddleName

-

Affiliation

Department of Analytical Chemistry, Faculty of Pharmacy, Sohag University, Sohag, 82524, Egypt

Email

ahmed_khorshed@pharm.sohag.edu.eg

City

-

Orcid

-

First Name

Wejdan, A.

Last Name

Aldajani

MiddleName

-

Affiliation

Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 2155, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Nisreen Abdullah

Last Name

Rajeh

MiddleName

-

Affiliation

Anatomy Department, medical college, KAU, Jeddah 2155, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Nada A.

Last Name

El-Shahawy

MiddleName

-

Affiliation

Institute of Animal Production Research, Dokki, Giza, Egypt

Email

-

City

-

Orcid

-

First Name

Soad

Last Name

Ali

MiddleName

-

Affiliation

Yousef Abdul Latif Jameel Scientific Chair of Prophetic Medicine Application, Faculty of Medicine,King Abdulaziz University, Jeddah 22254, Saudi Arabia, Department of Histology and Cell Biology, Faculty of Medicine, Assuit University, Assuit 98467, Egypt, Faculty of Medicine, Merit University, Sohag, 82524, Egypt

Email

-

City

-

Orcid

-

Volume

65

Article Issue

13

Related Issue

37459

Issue Date

2022-12-01

Receive Date

2022-05-21

Publish Date

2022-12-01

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_256568.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=256568

Order

256,568

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023