The aim of this study is to evaluate the UV-protective activity of nano-curcumin in a rat skin model and compare its results with a commercial sunscreen agent, phenylbenzimidazole-5-sulfonic acid (PBSA). Nano-curcumin were prepared and characterized by measuring their size distribution. The photoprotective potential was evaluated by histopathological examination of the skin. Results showed that skin group irradiated with UV showed a significant histopathological change, it showed skin thickening and necrosis of dermal collagen. On the other hand, treatment with nano-curcumin protected skin tissues against UV damage by restoring histopathology changes. The results revealed that nano-curcumin provide a significant protection to the skin tissues in comparison with conventional treatment by PBSA.