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233506

Upregulation of Long Non-coding RNA MEG3 and miR-181b in Type 2 Diabetic Patients with Cerebral Stroke

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Biochemistry

Abstract

Background and Aims

Several studies have demonstrated that long non-coding RNA (lncRNA) and microRNA (miRNA) molecules were closely related to the pathogenesis of diabetes mellitus (DM) and its complications. In this study, we aimed to explore the possible relationship of lncRNA MEG3 and miR-181b with the development of ischemic cerebral stroke (CS) as a complication of type 2 DM.

Methods

The study involved 20 diabetic patients (DM), 20 diabetic patients with CS (DM+CS), 17 CS patients and 10 apparently healthy subjects. The expression levels of MEG3 and miR-181b were analyzed in peripheral blood samples using real time PCR.

Results

The expression of MEG3 was significantly higher in both DM+CS and CS groups as compared to DM or control group. In addition, miR-181b was significantly upregulated in DM+CS and CS compared to control group.

Conclusions

This study suggested that MEG3 and miR-181b may play a role in the progression of CS in diabetic patients.

DOI

10.21608/ejchem.2022.128273.5701

Keywords

Cerebral stroke, MEG3, miR-181b, Type-2 diabetes mellitus

Authors

First Name

Heba

Last Name

Hassan

MiddleName

A.

Affiliation

Therapeutic Chemistry Department, National Research Centre (NRC), El-Bouth St., P.O. 12622 Cairo, Egypt

Email

hassan_heba59@yahoo.com

City

-

Orcid

-

First Name

Naglaa M.

Last Name

Ammar

MiddleName

-

Affiliation

Therapeutic Chemistry Department, National Research Centre (NRC), El-Bouth St., P.O. 12622 Cairo, Egypt

Email

naglaaammar@yahoo.com

City

-

Orcid

-

First Name

Olfat G.

Last Name

Shaker

MiddleName

-

Affiliation

Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

olfatshaker@yahoo.com

City

-

Orcid

-

First Name

Yasser I.

Last Name

Kandil

MiddleName

-

Affiliation

Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt

Email

kandil.yasser@azhar.edu.eg

City

Cairo

Orcid

0000-0002-7156-9208

First Name

Mahmoud Gomaa

Last Name

Eldeib

MiddleName

-

Affiliation

Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt

Email

eldeib85@gmail.com

City

-

Orcid

0000-0003-0476-4625

Volume

65

Article Issue

13

Related Issue

37459

Issue Date

2022-12-01

Receive Date

2022-03-21

Publish Date

2022-12-01

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_233506.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=233506

Order

233,506

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023