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233044

Formulation and Physicochemical Evaluation of Theophylline Nanoparticles Transdermal Patch

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Nanotechnology

Abstract

The objectives of this research were to formulate theophylline nanoparticles matrix transdermal patch with different ratios of hydroxypropyl methylcellulose and ethylcellulose polymer with ratio 90%:10% (F1), 80%:20% (F2), 70%:30% (F3), 60%:40% (F4), 50%:50% (F5), and to evaluate the physicochemical characteristic of the resulted matrix patch. Preparation of matrix patch was conducted by the solvent evaporation casting method. Physicochemical characteristics of the patch, including physical appearance, weight uniformity, thickness uniformity, pH, moisture content, tensile strength, and profile release, were evaluated. Permeation of drugs into the skin was assessed using a modified Franz diffusion cell. Observations of the physical appearance showed that matrix patches were transparent, smooth, and dry. Weight uniformity ranges were from 0.69 g to 0.77 g with thickness 0.14 mm to 0.22 mm. Moisture content ranges were 0.49% to 2.14%, and pH values were from 5.0 to 6.0. Tensile strength ranged between 1.19 and 3.41 N/mm2. Theophylline release of F1-F5 formulation was varied from 14.46% to 18.62% at 360 minutes, and all patches were capable of permeating through the rat skin membrane. Physicochemical evaluation of matrix patches showed that all patches fulfill the requirements of acceptable patches for transdermal administration.

DOI

10.21608/ejchem.2022.114370.5206

Keywords

formulation, theophylline nanoparticles, matrix transdermal patch, physicochemical evaluation

Authors

First Name

suryani

Last Name

Suryani

MiddleName

-

Affiliation

Department of Pharmacy, Faculty of Pharmacy, Halu Oleo University, Kendari, South East Sulawesi, Indonesia

Email

suryani@uho.ac.id

City

Kendari

Orcid

0000-0003-0259-5856

First Name

Muhamad

Last Name

Sahumena

MiddleName

Handoyo

Affiliation

Departement of Pharmacy, Faculty of Pharmacy, Halu Oleo University, Kendari, South East Sulawesi, Indonesia

Email

handoyosahumena@uho.ac.id

City

Kendari

Orcid

-

First Name

Waode

Last Name

Zubaydah

MiddleName

Sitti

Affiliation

Departement of Pharmacy, Faculty of Pharmacy, Halu Oleo University, Kendari, South East Sulawesi, Indonesia

Email

woszubaydah@uho.ac.id

City

Kendari

Orcid

-

First Name

Sitti Raodah

Last Name

Jannah

MiddleName

Nurul

Affiliation

Departement of Pharmacy, Faculty of Pharmacy, Halu Oleo University, Kendari, South East Sulawesi, Indonesia

Email

raodah2106@gmail.com

City

Kendari

Orcid

-

First Name

Sandra

Last Name

Mardikasari

MiddleName

Aulia

Affiliation

Departement of Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar South Sulawesi, Indonesia

Email

sandraaulia@unhas.ac.id

City

Kendari

Orcid

-

First Name

Muhammad

Last Name

Aswan

MiddleName

-

Affiliation

Pusdaya Indonesia, Kendari, South East Sulawesi, Indonesia

Email

aswan.muhammad.biologi@gmail.com

City

Kendari

Orcid

-

First Name

Andi Nafisah

Last Name

Adjeng

MiddleName

Tenri

Affiliation

Departement of Pharmacy, Faculty of Medicinal, Lampung University, Lampung, Sumatera, Indonesia

Email

andi.nafisah@fk.unila.ac.id

City

Kendari

Orcid

0000-0002-7186-7627

First Name

Michrun

Last Name

Nisa

MiddleName

-

Affiliation

Departement of Pharmacy, Sekolah Tinggi Ilmu Farmasi Makassar, South Sulawesi, Indonesia

Email

mnmichrunnisa84@gmail.com

City

Makassar

Orcid

-

First Name

Septiany

Last Name

Maria

MiddleName

Fransisca

Affiliation

Department of Pharmacy, Faculty of Pharmacy, Halu Oleo University

Email

fransiscasepty@gmail.com

City

Kendari

Orcid

-

Volume

65

Article Issue

13

Related Issue

37459

Issue Date

2022-12-01

Receive Date

2022-01-04

Publish Date

2022-12-01

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_233044.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=233044

Order

233,044

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Formulation and Physicochemical Evaluation of Theophylline Nanoparticles Transdermal Patch

Details

Type

Article

Created At

22 Jan 2023