Determination of cyflumetofen and sulfoxaflor residues in treated cucumber samples (Cucumis sativus), which were collected randomly 0, 1, 2, 3, 5, 7, 10, and 15 days after treatment using quick, easy, cheap, effective, rugged, safe (QuEChERS) and cleanup step utilizing dispersive solid-phase extraction (DSPE) and followed by determination high-performance liquid chromatography with diode-array detection (HPLC/DAD). Cyflumetofen was recovered within 87.60-99.43%, while sulfoxaflor was recovered within 80.85-100.14%, with relative standard deviations (RSDs), ranging from 3.97-6.21% and 3.46-5.94% respectively, in cucumber samples at the spike levels (0.1 - 1 mg/kg). Good linearity was achieved for cyflumetofen with an excellent correlation coefficient of R2> 0.99and sulfoxaflor also showed R2> 0.98. The initial deposits of cyflumetofen and sulfoxaflor averaged 1.44 and 2.29 mg/kg, respectively. The half-life period (RL50) of cyflumetofen and sulfoxaflor were 0.60 and 1.31 days, respectively. According to the maximum residue level (MRL), which reached 0.4 mg/kg for cyflumetofen and 0.5 mg/kg for sulfoxaflor, the pre-harvest interval (PHI) was 3 days and 7 days, respectively.