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229425

The Effectiveness of Begonia Multangula Blume Leaf Ethanol Extract as Polymicrobial Antibiofilm on Catheters

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Pharmaceutical Chemistry

Abstract

The growth of catheter biofilm is associated with urinary tract nosocomial infections and causes an increase in mortality every year. Begonia Multangula Blume leaves are known have antibacterial activity but their antibiofilm activity has not been reported. This study aimed to determine the effectiveness of Begonia Multangula Blume extract in inhibiting polymicrobials in catheters. The research was conducted using the microtiter broth method. Antibiofilm activity was determined as the minimum biofilm inhibitory concentration (MBIC50), the minimum biofilm eradication concentration (MBEC50). Antibiofilm mechanism elucidated using scanning electron microscopy (SEM). Statistical analyzes were performed using ANOVA (P <0.05). Begonia Multangula blume leaf extract 1% v/v gave inhibitory activity of polymicrobial biofilm formation in the middle phase catheter of 65.23 % ± 0.01 and maturation phase of 60.44 % ± 0.01 almost equivalent to the control drugs chloramphenicol and nystatin 1 % v/v. The results provide evidence that the leaves of Begonia Multangula blume can eradicate 60% polymicrobial biofilms 63.55 % ± 0.01. Observations using SEM showed disruption the Extracellular Polymeric Substances (EPS) layer due to the test compound. The conclusion of this study, that Begonia Multangula blume leaf ethanol extract has the potential to be developed as a candidate for new antibiofilm drugs against polymicrobial biofilms on catheters

DOI

10.21608/ejchem.2022.118622.5341

Keywords

Antibiofilm, Begonia multangula Blume, Catheter, Infection, Polymicrobial Biofilm

Authors

First Name

Asriullah

Last Name

Jabbar

MiddleName

-

Affiliation

Department of Pharmacy, Faculty of Pharmacy, Universitas Halu Oleo, Kendari, 93232, Indonesia.

Email

asriullah.jabbar@gmail.com

City

kendari

Orcid

0000-0001-8319-6341

First Name

Hasyrul

Last Name

Hamzah

MiddleName

-

Affiliation

Faculty of Pharmacy, Universitas Muhammadiyah Kalimantan Timur, Samarinda, Kalimantan Timur, 75124, Indonesia.

Email

hh241@umkt.ac.id

City

Samarinda

Orcid

0000-0001-5806-1760

First Name

Erika

Last Name

Nandini

MiddleName

-

Affiliation

Faculty of Pharmacy, Universitas Muhammadiyah Kalimantan Timur, Samarinda, Kalimantan Timur, 75124, Indonesia.

Email

erikanandini2019@gmail.com

City

Samarinda

Orcid

-

First Name

Ari

Last Name

Nurwijayanto

MiddleName

-

Affiliation

Balai Taman Nasional Gunung Merapi, Jl. Kaliurang KM 22,6, Hargobinangun, Pakem, Area Hutan, Hargobinangun, Kec. Pakem, Kabupaten Sleman, Daerah Istimewa Yogyakarta 55582 Indonesia.

Email

arinur80@gmail.com

City

Yogyakarta

Orcid

-

First Name

Endang

Last Name

Setyowati

MiddleName

-

Affiliation

Faculty of Health Science, Pharmacy Study Program, Univewrsitas Muhammadiyah Kudus, Jawa Tengah, 59316, Indonesia.

Email

endangsetyowati@umkudus.ac.id

City

Kudus

Orcid

-

First Name

Syamsuri

Last Name

Syakri

MiddleName

-

Affiliation

Department of Pharmacy, Faculty of Medicine and Health Science, Universitas Islam Negeri Alauddin, Makassar, Indonesia.

Email

syamsurisyakri@gmail.com

City

Makassar

Orcid

-

First Name

Hifdzur

Last Name

Rija&rsquo;i

MiddleName

Rashif

Affiliation

Pharmaceutical Research and Development Laboratory of Pharmaca Tropis Pharmacy Faculty, Universitas Mulawarman, Kalimantan Timu, Samarinda, Indonesia.

Email

hifdzurrashifrija@farmasi.unmul.ac.id

City

Samarinda

Orcid

-

First Name

Mubarak

Last Name

Mubarak

MiddleName

-

Affiliation

Faculty of medicine, Universitas Halu Oleo, Kendari Indonesia

Email

mubarak@uho.ac.id

City

Kendari

Orcid

0000-0001-9053-2761

Volume

65

Article Issue

13

Related Issue

37459

Issue Date

2022-12-01

Receive Date

2022-01-28

Publish Date

2022-12-01

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_229425.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=229425

Order

229,425

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

The Effectiveness of Begonia Multangula Blume Leaf Ethanol Extract as Polymicrobial Antibiofilm on Catheters

Details

Type

Article

Created At

22 Jan 2023