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Effect of Ginkgo biloba leaf extract in combination with vitamin C, E and D on Aluminum Chloride induced Alzheimer in rats.

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Biochemistry

Abstract

Alzheimer's disease(AD), is a neurodegenerative ailment and the most prevalent cause of dementia. The commonly used synthetic drugs provide temporary and incomplete symptomatic treatment accompanied with severe side effects. The present study aimed at evaluating the therapeutic potential of Ginko Biloba, and/ or Vitamin D, E, C on aluminum chloride (AlCl3)-induced neurotoxicity in rats.

AD was induced in rats by oral administration of AlCl3 (17 mg/kg BW) for 1 month. Rats were treated with Ginko Biloba methanolic leaf extract (400 mg/kg.BW/day), vitamin D3 (0.0125 mg/kg.BW/day), E(2.5mg/kg.BW/day), Vitamin C (50mg/kg.BW/day) and their combinations, respectively, for 15 days. Behavioral assessment was carried out using Y-maze test. The activity of acetylcholinesterase, Dopamine, Serotonin and Nor-Epinephrine; in addition, histopathological examination of the isolated Hippocampal brain tissues were done. It was observed that administration of Ginko biloba in combination with vitamin C attenuated memory impairment and improved cholinergic and dopaminergic dysfunction. Also, significant improvement in histopathological alterations and hippocampal morphology was noticed. It could be concluded that Ginko biloba and /or vitamin C exhibited significant improvement in memory loss and neurotoxicity and could be an effective treatment against cognitive decline in AD patients.

DOI

10.21608/ejchem.2022.133257.5889

Keywords

Alzheimer’ s disease, Neurotoxicity, Ginko biloba, vitamin c, Y-maze, Neurotransmitter

Authors

First Name

Salwa

Last Name

elhallouty

MiddleName

Mahmoud

Affiliation

Pharmacognosy Department, National Research Centre

Email

-

City

Giza

Orcid

-

First Name

Anan

Last Name

Rashad

MiddleName

Mohamed

Affiliation

Biotechnology Department, Faculty of Science, Cairo University

Email

ananmrashad56@gmail.com

City

-

Orcid

0000-0002-5593-3583

First Name

Esraa

Last Name

Abd elrhman

MiddleName

Ayman

Affiliation

Biotechnology Department, Faculty of Science, Cairo University

Email

esraa99ayman@gmail.com

City

-

Orcid

0000-0003-3047-3645

First Name

Haidy

Last Name

Elkaramany

MiddleName

Amr Khaled

Affiliation

Biotechnology Department , Faculty of Science, Cairo University.

Email

dalidakaramany@gmail.com

City

-

Orcid

0000-0002-7196-0426

First Name

Maria

Last Name

Ibrahim

MiddleName

Gamal

Affiliation

Biotechnology Department, Faculty of Science, Cairo University

Email

gamalibrahim312@gmail.com

City

-

Orcid

0000-0002-0302-4476

First Name

Nouran

Last Name

Salem

MiddleName

Tamer

Affiliation

Biotechnology Department, Faculty of Science, Cairo University

Email

nourantamer27@gmail.com

City

-

Orcid

0000-0002-9042-5082

First Name

Reeny

Last Name

Adeeb

MiddleName

Ayman

Affiliation

Biotechnology Department, Faculty of Science, Cairo University

Email

renyayman113@gmail.com

City

-

Orcid

0000-0003-2864-883x

First Name

Yehia

Last Name

Ibrahim

MiddleName

Walaa

Affiliation

Biotechnology Department, Faculty of Science, Cairo University

Email

yehyawalaa.48@gmail.com

City

-

Orcid

0000-0002-8910-4214

First Name

Zeinab

Last Name

El Shahed

MiddleName

Abd Elkhalek

Affiliation

National research center

Email

dr.z.a.elshahid@gmail.com

City

Nasr city

Orcid

0000-0001-8237-9568

Volume

65

Article Issue

13

Related Issue

37459

Issue Date

2022-12-01

Receive Date

2022-04-13

Publish Date

2022-12-01

Page Start

827

Page End

841

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 13_Pages 827-841.pdf

PDF . 1.5MB

Link

https://ejchem.journals.ekb.eg/article_242932.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=242932

Order

242,932

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Effect of Ginkgo biloba leaf extract in combination with vitamin C, E and D on Aluminum Chloride induced Alzheimer in rats.

Details

Type

Article

Created At

22 Jan 2023