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246199

Pseurotin A Halts Hepatocellular Carcinoma Oncogenic Potential Through Tuning miR-30a and let-7i Tumor Suppressor miRNAs

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Biochemistry

Abstract

Hepatocellular carcinoma (HCC) is a global health challenge with a predicted high mortality rate in the future. Thus, discovering novel natural metabolites trimming the progression of HCC is an urgent necessity. In this study, we aimed to evaluate the effect of cytotoxic alkaloids isolated from endophytic fungus Aspergillus fumigatus, extracted from Albizia lucidior leaves (Fabaceae), against Huh7 cells and to further reveal their possible mechanisms on TP53 and c-Myc and their downstream tumor suppressor microRNAs (miRNAs). Pseurotin A and chaetominine revealed a concentration and time-dependent inhibition in cellular viability of Huh7 cells as well as significant repression in the proliferation and clonogenic capacities of Huh7 cells, compared to vehicle control. Pseurotin A exhibited more potent effects in halting Huh7 tumorigenic activity than chaetominine. Restoration of TP53, c-Myc, and their downstream tumor suppressor miRNAs; miR-30a, let-7i was achieved by pseurotin A only. Therefore, this study highlights a novel role of alkaloidal compounds from A. fumigatus in controlling the progression of HCC.

DOI

10.21608/ejchem.2022.141384.6186

Keywords

Aspergillus fumigatus, Albizia lucidior, Pseurotin A, Huh7, TP53, miRNAs

Authors

First Name

Mai

Last Name

Hussein

MiddleName

E

Affiliation

Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr el Aini St., Cairo, Egypt

Email

mai.husein@pharma.cu.edu.eg

City

-

Orcid

0000-0002-8838-8147

First Name

Amira

Last Name

El-Senousy

MiddleName

S

Affiliation

Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr el Aini St., Cairo, Egypt

Email

amira.elsenousy@pharma.cu.edu.eg

City

cairo

Orcid

0000-0003-3418-7320

First Name

Hesham

Last Name

El-Askary

MiddleName

I

Affiliation

Department of Pharmacognosy ,Faculty of Pharmacy ,Cairo University ,Cairo

Email

hesham.elaskary@pharma.cu.edu.eg

City

cairo

Orcid

0000-0001-7764-6588

First Name

Ahlam

Last Name

El Fishawy

MiddleName

M

Affiliation

Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr el Aini St., Cairo, Egypt

Email

ahlam.elfishawy@pharma.cu.edu.eg

City

cairo

Orcid

-

First Name

Ahmed

Last Name

Hamed

MiddleName

A

Affiliation

National research center, Cairo Microbial Chemistry department, National Research Centre, 33 El-Buhouth Street,

Email

ahmedshalbio@gmail.com

City

Dokki

Orcid

0000-0002-9997-9284

First Name

Rana

Last Name

Youness

MiddleName

A

Affiliation

Biology and Biochemistry Department, School of Life and Medical Sciences, University of Hertfordshire Hosted By Global Academic Foundation, New Administrative Capital, Cairo, Egypt

Email

rana.youness21@gmail.com

City

cairo

Orcid

-

Volume

65

Article Issue

13

Related Issue

37459

Issue Date

2022-12-01

Receive Date

2022-05-28

Publish Date

2022-12-01

Page Start

501

Page End

509

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 13_Pages 501-509.pdf

PDF . 918.7kB

Link

https://ejchem.journals.ekb.eg/article_246199.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=246199

Order

246,199

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Pseurotin A Halts Hepatocellular Carcinoma Oncogenic Potential Through Tuning miR-30a and let-7i Tumor Suppressor miRNAs

Details

Type

Article

Created At

22 Jan 2023