As a natural raw waste of agricultural origin, sugarcane bagasse has several potential future applications upon converting into promising products. Both alkaline-treated solution and cellulose pulp were used for preparation of antifungal silica-based nanoparticles (Si-NPs) beside glucose and production. Adopting the agar-disc diffusion technique, nanosilica successfully exhibited in vitro antifungal activity towards the pathogen Fusarium solani, inhibition zones of 0.4-0.9 mm dia. were measured. In a pot experiment, increasing levels of NPK fertilization regimes and Si-NPs were examined for protecting potatoes from the fungal attack. The highest rates of both amendments supported sufficient tuber yield and vegetative growth, plants heavily dressed hosted 9-25 tubers plant-1 with fresh weights of 159.9-550.6 g plant-1. The pathogenicity of F. solani towards the vegetable plant significantly diminished in presence of NPK and Si-NPs. Tuber biomasses positively correlated with NPK doses (r, 0.918) and Si-NP rates (r, 1.00), except the low level of 25 % that failed to promoted growth and yield even in presence of full NPK regime. A. niger succeeded to convert cellulose pulp into reducing sugars and ß. glucosidase. The enzyme production significantly optimized after 12 hr. incubation at 200 rpm particularly in culture medium amended with 3 % corn speed liquor. Interestingly, adding 5 ml drop-wise distilled water to β. glucosidase production medium seemed necessary to avoid the feedback inhibition of the enzyme.