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Phytochemical Profile, Anti-lipid peroxidation and Anti-diabetic activities of Thymus algeriensis Boiss. & Reut

Article

Last updated: 01 Jan 2025

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Tags

Pharmaceutical Chemistry

Abstract

Thymus algeriens Bioss & Reut is an Algerian native plant traditionally used for culinary and medicinal purposes. Biological activities varied with their chemical composition, which depends on the floral and geographical origin. This study was designed to screen the phenolic content of the n-BuOH extract of Thymus algeriensis (BETA), anti-lipid peroxidation and anti-diabetic properties on different in vitro models. The results showed, that BETA reduced TBARS formation in a concentration-dependent manner; protected β-carotene from auto-oxidation and prevented oxidation of ferrous in the linoleic acid/ferric thiocyanate assay. Furthermore, BETA showed effective inhibitions of the key enzymes linked to type 2 diabetes; 𝛼-amylase and 𝛼-glucosidase. BETA blocked also the formation of AGE as shown by the results of glucose-BSA (BSA-GLU), BSA-Methylglyoxal system (BSA-MGO) and glycated hemoglobin. The effectiveness of BETA in combating diabetics might be influenced by the synergistic action of its phenolic compounds; mentioned by the phenolic content and LC/MS analysis; particularly their richness on the rosmarinic acid and ferulic acid, cafeic acid as well quercetin. This suggests the potential of BETA to mitigate multiple complications stemming from oxidative stress and protein glycation in diabetes.

DOI

10.21608/ejchem.2022.126336.5600

Keywords

Thymus algeriensis, LC-MS, Anti-glycation, Anti-lipid peroxidation, α-glucosidase, 𝛼-amylase

Authors

First Name

Zaoui

Last Name

Heyem

MiddleName

-

Affiliation

Laboratoire de Biologie et Environnement, Faculté de Sciences de la Nature et de la vie, Université Constantine 1, 25000 Constantine, Algérie

Email

zaoui.hayem@gmail.com

City

Constantine

Orcid

-

First Name

Boutaoui

Last Name

Nassima

MiddleName

-

Affiliation

Unité de recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Frères Mentouri Constantine1, Algérie

Email

boutaoui.nassima@gmail.com

City

Constantine

Orcid

-

First Name

Menad

Last Name

Ahmed

MiddleName

-

Affiliation

Laboratory of Biology and Environment, Faculty of Nature and Life Sciences, University Mentouri Brothers Constantine 1 BP, 325 Ain El bey way, Constantine 25017-Algeria

Email

menadahmed@yahoo.fr

City

Constantine

Orcid

https://orcid.org/00

First Name

Ramazan

Last Name

Erenler

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Arts and Sciences, Tokat Gaziosmanpaşa University, Tokat, Turkey

Email

ramazan.erenler@gop.edu.tr

City

Tokat

Orcid

-

First Name

Zaiter

Last Name

Lahcene

MiddleName

-

Affiliation

Unité de recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Frères Mentouri Constantine1, Algérie

Email

lahcene.zaiter@yahoo.fr

City

Constantine

Orcid

-

First Name

Benayache

Last Name

Fadila

MiddleName

-

Affiliation

Unité de recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université Frères Mentouri Constantine1, Algérie

Email

fbenayache@yahoo.fr.com

City

Constantine

Orcid

http://orcid.org/000

First Name

Souad

Last Name

Ameddah

MiddleName

-

Affiliation

Laboratory of Biology and Environment, Faculty of Nature and Life Sciences,University Mentouri Brothers

Email

amedsouad@yahoo.fr

City

Constantine

Orcid

https://orcid.org/00

Volume

65

Article Issue

12

Related Issue

35799

Issue Date

2022-12-01

Receive Date

2022-03-09

Publish Date

2022-12-01

Page Start

695

Page End

705

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 12_Pages 695-705.pdf

PDF . 499.7kB

Link

https://ejchem.journals.ekb.eg/article_232586.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=232586

Order

232,586

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Phytochemical Profile, Anti-lipid peroxidation and Anti-diabetic activities of Thymus algeriensis Boiss. & Reut

Details

Type

Article

Created At

22 Jan 2023