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226472

Synthesis and biological activity evaluation of some novel heterocyclic compounds incorporating pyridine / chromene moiety

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

4-Bromoacetyl pyridine 2a and 3-bromoacetylcoumarine 2b react with malononitrile 3 and thiourea 6 to afford the furan and the thiazole derivatives 5a,b and 7a,b respectively. The thiazoles 7a,b react with DMFDMA 8, phenyl isothiocyanate 10, acetic anhydride 12 and ethyl cyanoacetate 14 to afford the thiazole derivatives 9-13a,b and the thiazolo[3,2-a]pyrimidinone derivatives 16a,b respectively. All structures are proven by analysis and spectral methods. The biological activity of the synthesized compounds was screened as anti bacterial and anti fungal agents.

DOI

10.21608/ejchem.2022.127181.5653

Keywords

Acetyl pyridine, acetyl coumarine, Furans, Thiazoles, thiazolo[3, 2-a]pyrimidine derivatives

Authors

First Name

Fathy

Last Name

Abdel-Razek

MiddleName

Mohamed

Affiliation

Chemistry Department, Faculty of Science, Cairo University

Email

prof.fmrazek@gmail.com

City

-

Orcid

-

First Name

Ali

Last Name

Hebishy

MiddleName

M. S.

Affiliation

Faculty of Science, Helwan University

Email

ashebishy@gmail.com

City

Cairo

Orcid

-

First Name

Rewaida

Last Name

Ali

MiddleName

H.

Affiliation

External

Email

rewaidaharby@gmail.com

City

Giza

Orcid

-

Volume

65

Article Issue

12

Related Issue

35799

Issue Date

2022-12-01

Receive Date

2022-03-13

Publish Date

2022-12-01

Page Start

569

Page End

576

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 12_Pages 569-576.pdf

PDF . 658.0kB

Link

https://ejchem.journals.ekb.eg/article_226472.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=226472

Order

51

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Synthesis and biological activity evaluation of some novel heterocyclic compounds incorporating pyridine / chromene moiety

Details

Type

Article

Created At

22 Jan 2023