This experiment was conducted in the greenhouse of the National Research Centre during the two seasons of 2019/2020 and 2020/2021 to study the ability of Dimorphotheca ecklonis plants to grow in the soil contaminated with cadmium (Cd) at different concentrations (0, 25, 50 and 100 mg. kg-1 soil), the humic acid was used at concentrations (0, 200 and 400 mg. l-1) to improve the plants growth. The plants grown in soil contaminated with Cd at 25mg. kg-1 soil gave the highest mean values of all vegetative growth parameters, photosynthetic pigments and total sugar content; whereas, the plants grown in soil free of cadmium gave the highest mean values for RWC% and all inflorescences parameters in both seasons. The treatment Cd 100 mg. kg-1 increased the leaves content of total phenol, total proline, MDA content and cadmium content in both shoot and root in both seasons. The plants that received humic acid (HA) at concentration 200 mg. l-1 showed significantly increase for all vegetative growth parameters, RWC%, all inflorescences parameters, photosynthetic pigments,total sugar content and total phenol content in both seasons, while; proline and MDA content were increased at control HA treatments, Cd content in shoot and root were increased by HA 400mg. l-1. Regarding the interaction treatments the plants treated with Cd at 25 mg. kg-1 and HA at 200 mg. l-1 increased all vegetative growth parameters, photosynthetic pigments and total sugar content in both seasons, while; the treatment Cd at 0mg. kg-1 and HA at 200 mg. l-1 significantly increased RWC% and inflorescences parameters, the highest value of total phenol content were produced by treatment Cd at 100 mg. kg-1 and HA at 400 mg. l-1, proline content and MDA by treatment Cd at 100 mg. kg-1 and HA at 0 mg. l-1 and Cd content in shoot and root by treatment Cd at 100 mg. kg-1 and HA at 400 mg. l-1. Polyphenol oxidase and peroxidase isoenzymes showed overexpression in treatment Cd at 100 mg. kg-1 and HA at 400 mg. l-1 in the second season.