Hyperlipidemia is the major risk factor for cardiovascular disease which is one of the main cause of death. Some oils have the ability to control hyperlipidemia.

This study aimed to evaluate the effect of sesame, flaxseed and chia oils on lipid profile, histophathological parameters, body weight and oxidative stress in rats fed basal diet as well as the effectiveness of these oils in preventing hyperlipidemia and its damage when eating high fat diet (HFD) rats were divided into two mine groups, one fed basal diet and the other groups fed high fat diet (HFD), each group was divided into four 4 subgroups, one served as control and the other three subgroup received flaxseed, sesame or chia oils instead of corn oil, lipid parameters, histophathological stream of liver and kidney, weight as well as oxidative stress of liver were monitored .

Our results revealed that experimental oils had a remarkable effect in controlling increment of triglycerides (TG) total cholesterol, Low density lipoprotein (LDL) and furthermore improve liver and kidney histopathology tissues as nearly close to normal and also ameliorate oxidative stress.