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222265

Potential anti-dyslipidemia and hepatoprotection of functional food ‎components represented by tetracosanol and mixture of policosanol in Triton ‎X-100 induced dyslipidemic rats ‎

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Biochemistry

Abstract

The elevated plasma triglycerides (TGs), total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) with ‎concomitant reduction of high density lipoprotein-cholesterol (HDL-C) are designated as dyslipidemia. The aim of the ‎present research was to study the protective effect of tetracosanol and policosanol mixture towards triton X-100 induced ‎dyslipidemia along with their hepatoprotective effect in rats. The policosanol mixture was prepared from tetracosanol, ‎hexacosanol, octacosanol and heptacosanol in the ratio of 3:1:1:1. Rats were divided into 4 groups; a normal control (NC), ‎dyslipidemic control (DC) and two test groups with dyslipidemia and treated with either tetracosanol or policosanol mixture ‎in the form of emulsions. The determined biochemical parameters were plasma TGs, TC, LDL-C, HDL-C, malondialdehyde ‎‎(MDA) and the activities of alanine transaminase (ALT) and aspartate transaminase (AST). In addition to calculation of ‎TC/HDL-C and LDL-C/HDL-C as the elevation of such ratios are considered risk factors for cardiovascular diseases ‎‎(CVDs). Histopathological examination of liver was also carried out. Results showed significant dyslipidemia and elevated ‎LDL-C/HDL-C, TC/HDL-C, MDA, ALT and AST with liver histopatological changes in the DC group compared to the NC ‎group. Both tetracosanol and policosanol mixture reduced the risk factors for CVDs and improved the dyslipidemia, ‎oxidative stress and liver function. Tetracosanol was superior in reducing TC, ALT and AST and improving liver ‎histopathology while policosanol mixture was more efficient in reducing oxidative stress. ‎

DOI

10.21608/ejchem.2022.121634.5452

Keywords

Triton X-100, dyslipidemia, Malondialdehyde, liver histopathology, tetracosanol, policosanol mixture, rats.‎

Authors

First Name

Sahar

Last Name

Al-Okbi

MiddleName

-

Affiliation

Department of nutrition and Food Sciences, National Research Centre, Cairo, Egypt

Email

s_y_alokbi@hotmail.com

City

-

Orcid

‎0000-0002-8114-2718

First Name

Enas

Last Name

Al-Siedy

MiddleName

S.K.

Affiliation

Nutrition and Food Sciences Department, National Research Centre, Cairo, Egypt.

Email

enassabry1211@hotmail.com

City

Cairo

Orcid

‎000-0002-1368-171X‎

Volume

65

Article Issue

11

Related Issue

35761

Issue Date

2022-11-01

Receive Date

2022-02-13

Publish Date

2022-11-01

Page Start

313

Page End

321

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_222265.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=222265

Order

28

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Potential anti-dyslipidemia and hepatoprotection of functional food ‎components represented by tetracosanol and mixture of policosanol in Triton ‎X-100 induced dyslipidemic rats ‎

Details

Type

Article

Created At

22 Jan 2023