Beta
ManageSearchChatDiscover
223903

Characterization of Dry Powder Inhaler Quercetin Solid Lipid Microparticle (SLM) as Lung Delivery System: Effect of Polymer Concentration

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Pharmaceutical Chemistry

Abstract

The inhalation route for pulmonary treatment can provide many advantages such as high surface area with fast absorption due to high vascularity, avoiding the first pass effect, therapeutic effect can be achieved at much lower doses, as well as targeted drug delivery so as to reduce side effects. Solid lipid microparticle system containing Quercetin which was formed as Dry Powder using glyceryl behenate as lipid and poloxamer 188 as surfactant polymer was prepared. The system was characterised in terms of moisture content, morphology, particle size, flow properties, aerosolization study, mass median aero dynamic (MMAD) and in vitro release. Size and morphology was spherical and smooth with dry and small size met inhalation size (

DOI

10.21608/ejchem.2022.120170.5393

Keywords

SLM, Quercetin, inhalation, lung disease, Poloxamer 188

Authors

First Name

DEWI

Last Name

HARIYADI

MiddleName

MELANI

Affiliation

Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Campus C Jl. Mulyorejo Surabaya, Indonesia

Email

dewi-m-h@ff.unair.ac.id

City

Surabaya

Orcid

0000-0001-9357-3913

First Name

Iqlima

Last Name

Prestisya

MiddleName

-

Affiliation

Faculty of Pharmacy Universitas Airlangga, Campus C Jl. Mulyorejo

Email

iqlimayu55@gmail.com

City

Surabaya

Orcid

-

First Name

Gatot

Last Name

Suhariyono

MiddleName

-

Affiliation

Pusat Teknologi Keselamatan dan Metrologi Radiasi – BATAN, Indonesia

Email

g.suhariyono@batan.go.id

City

-

Orcid

-

First Name

Andangndang

Last Name

Miatmoko

MiddleName

-

Affiliation

Faculty of Pharmacy Universitas Airlangga, Campus C Jl. Mulyorejo

Email

andang-m@ff.unair.ac.id

City

Surabaya

Orcid

-

First Name

Noorma

Last Name

Rosita

MiddleName

-

Affiliation

Faculty of Pharmacy Universitas Airlangga, Campus C Jl. Mulyorejo Campus C Jl. Mulyorejo

Email

itanr@yahoo.com

City

Surabaya

Orcid

-

First Name

Mahardian

Last Name

Rahmadi

MiddleName

-

Affiliation

Faculty of Pharmacy Universitas Airlangga, Campus C Jl. Mulyorejo

Email

mahardian-r@ff.unair.ac.id

City

Surabaya

Orcid

-

Volume

65

Article Issue

11

Related Issue

35761

Issue Date

2022-11-01

Receive Date

2022-02-05

Publish Date

2022-11-01

Page Start

281

Page End

289

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 11_Pages 281-289.pdf

PDF . 542.9kB

Link

https://ejchem.journals.ekb.eg/article_223903.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=223903

Order

24

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Characterization of Dry Powder Inhaler Quercetin Solid Lipid Microparticle (SLM) as Lung Delivery System: Effect of Polymer Concentration

Details

Type

Article

Created At

22 Jan 2023