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In Vitro antioxidant and cytotoxic evaluation of ethyl acetate fraction of Angiopteris ferox Copel tuber against HTB lung cancer cell

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Pharmaceutical Chemistry

Abstract

The tubers of Angiopteris ferox Copel from the Mirrataceae family have been widely used empirically by society for various treatments. This experimentation aimed to discover the antioxidant and anticancer action of the ethyl acetate (EA) fraction of Angiopteris ferox Copel tubers against HTB lung cancer and normal cells in vitro. The EA-fraction obtained from the liquid-liquid extraction was tested for antioxidant activity using the beta carotene degradation and the hydroxyl radical method. The EA-fraction tries the cytotoxic sequel on lung cancer and normal cells using the MTT test method. The outcome achieved that the EA-fraction of the sample has antioxidant activity in reducing lipid peroxidation radicals with an IC50 grade of 30.29 µg /mL (extreme category) and hydroxyl radicals with an IC50 grade of 126.62 µg /mL (medium category). In cytotoxic activity has a medium toxic effect on pulmonary HTB cell line with an IC50 grade of 78.96 µg /mL.
In comparison, normal Vero cells have a feeble harmful impact with an IC50 rate >500 µg /mL. It could have culminated that the EA-fraction of Angiopterix ferox Copel has antiradical activity and has a toxic effect on HTB cancer cells but is weak against normal Vero cells. It shall promote as a remedy for the management of lung cancer.

DOI

10.21608/ejchem.2022.91843.4364

Keywords

Angiopteris ferox Copel, antioxidant, cytotoxic, HTB cells, Vero cells

Authors

First Name

Andi

Last Name

Aisyah

MiddleName

Nur

Affiliation

Department of Pharmaceutical, Sekolah Tinggi Ilmu Farmasi Makassar

Email

andi.nuraisyah04@gmail.com

City

Makassar

Orcid

0000-0002-5243-384X

First Name

Endang

Last Name

Lukitaningsih

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gadjah Mada, Yogyakarta, Indonesia

Email

lukitaningsih_end@ugm.ac.id

City

Yogyakarta

Orcid

0000-0002-4969-5128

First Name

Rumiyati

Last Name

Rumiyati

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gadjah Mada, Yogyakarta, Indonesia

Email

rumiyaris@ugm.ac.id

City

Yogyakarta

Orcid

-

First Name

Marwati

Last Name

Marwati

MiddleName

-

Affiliation

Department of Pharmaceutical Biology

Email

watimar514@gmail.com

City

Makassar

Orcid

0000-0001-5243-9048

First Name

Amriani

Last Name

Sapra

MiddleName

-

Affiliation

Department of Pharmaceutical, Sekolah Tinggi Ilmu Farmasi Makassar

Email

amriani.sapra@gmail.com

City

Makassar

Orcid

0000-0001-7474-9290

First Name

Nur

Last Name

Khairi

MiddleName

-

Affiliation

Department of Pharmaceutical Technology, Sekolah Tinggi Ilmu Farmasi Makassar, Indonesia 90242

Email

nurkhairijalil@gmail.com

City

Makassar

Orcid

-

First Name

Alfat

Last Name

Fadri

MiddleName

-

Affiliation

Department of Pharmaceutical Chemsitry, Sekolah Tinggi Ilmu Farmasi Makassar

Email

alfatfadri@gmail.com

City

Makassar

Orcid

0000-0002-0751-0404

First Name

Syamsu

Last Name

Nur

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Sekolah Tinggi Ilmu Farmasi Makassar

Email

syamsunur19@gmail.com

City

-

Orcid

0000-0001-7730-4414

Volume

65

Article Issue

11

Related Issue

35761

Issue Date

2022-11-01

Receive Date

2021-08-22

Publish Date

2022-11-01

Page Start

41

Page End

48

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 11_Pages 41-48.pdf

PDF . 619.7kB

Link

https://ejchem.journals.ekb.eg/article_223517.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=223517

Order

5

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

In Vitro antioxidant and cytotoxic evaluation of ethyl acetate fraction of Angiopteris ferox Copel tuber against HTB lung cancer cell

Details

Type

Article

Created At

22 Jan 2023