A study of the influence of silica nanoparticles' size and concentration on the cotton woven fabric was the main objective of this paper. Silica NPs were synthesized using the Sol technique. Three sizes and three concentrations for each particle size were prepared and cotton woven fabrics were coated using the nine patches. Using SEM, TEM, and FTIR, the prepared particles were analyzed. The influence of Silica nanoparticles' size and concentration on antibacterial activity, roughness values, tensile strength, and air permeability of the coated woven fabrics were also investigated. The statistical analysis was conducted to assess the significant effects of silica NPs' size and concentration on fabric properties.