In this study, polypropylene (PP)/nano-hydroxyapatite (HA) nanocomposites were prepared using a twin-screw extruder to investigate the effect of different weight percentages of nano-HA (1, 2, and 3 wt.%) on the mechanical and tribological properties of PP. The tensile properties (i.e., tensile strength, modulus, and elongation at break) of the nanocomposites were determined; also, hardness, wear properties, and Fourier transform spectroscopy (FTIR), Scanning electron microscope (SEM), Differential scanning calorimetry (DSC) and contact angle (CA) were performed. The tensile test results showed that tensile strength and elongation increased to 23 MPa at 2% wt. of HA, while both Modulus and hardness increased with the increase in nano-HA content. By contrast, the wear rate and coefficient of friction (COF) decreased with the increase in nano-HA content. The FTIR results showed that only a physical interaction occurred between PP and nano-HA. SEM images indicate that there is a good dispersion of nano-HA within PP matrix. DSC results show that thermal stability improved with the addition of nanoHA.