This work presented a batch and kinetic study on the possibility of using concrete demolition wastes grafted with 3-aminopropyltriethoxysilane (APTES) as a reactive material in a Permeable reactive barrier PRB technology to remediate the ciprofloxacin (CPX) contaminated groundwater followed by evaluating the performance of this barrier by simulating the remediation process using two-dimensional aquifer model by COMSOL Multiphysics 3.5a program. To make this work more realistic, real groundwater was used in addition to distilled water in preparing the CPX contaminated groundwater. Several parameters that influence the sorption process were studied to achieve the highest removal percent such as contact time, pH, and sorbent dosage. Langmuir and Freundlich isotherm models were used to depict sorption data, moreover, the pseudo-first-order and pseudo-second-order models were applied in the kinetic study. The best values of the parameters that achieved the highest removal percent (93%), as confirmed by the batch experiments, were time=120min, pH=7, and dosage=1.5g/50mL. In addition, the two-dimensional aquifer model shows that the CPX propagation was restricted by a reactive barrier.