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221194

Comparative characterization of carob pulp and seeds extracts: HPLC, antimicrobial, anti-inflammatory, and cytotoxic studies

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

HPLC profile, antimicrobial, cytotoxic, and anti-inflammatory activities of carob (Ceratonia siliqua L.) pulp and seeds extracts were investigated. Gallic acid was the main identified phenolic. Ellagic acid, rutin, quercetin, and kaempferol were also tentatively identified. Carob seeds extract exhibited antimicrobial activity against Pseudomonas aeruginosa (6.25 and 25 mg mL-1 for minimum inhibitory concentration and minimum bactericidal concentration: respectively). Carob extracts showed a weak dose-response inhibition of the lipopolysaccharide induced nitric oxide release in RAW macrophages. Carob extracts even in the high dose did not inhibit the cell growth either against MCF-7 or HT-29 cell lines. Carob pods could be used as a functional food or food additive based on these findings.

DOI

10.21608/ejchem.2022.116534.5265

Keywords

carob, Phenolics, HPLC, cytotoxic, Antimicrobial, Anti-inflammatory

Authors

First Name

Alaadin

Last Name

El-Haddad

MiddleName

E.

Affiliation

faculty of pharmacy October 6 university

Email

alaa_elhaddad.ph@o6u.edu.eg

City

-

Orcid

0000-0002-3924-9263

First Name

Abdallah

Last Name

Gendy

MiddleName

M.

Affiliation

Pharmacology and Toxicology Department, Faculty of Pharmacy, October 6 University, Giza, Egypt.

Email

abdallahmohammed@o6u.edu.eg

City

6 October city

Orcid

0000-0001-5032-3594

First Name

Mohamed

Last Name

Amin

MiddleName

M.

Affiliation

Pharmacology Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Giza, Egypt

Email

mohamedmahmoud1983@gmail.com

City

-

Orcid

0000-0002-3602-5555

First Name

Walaa

Last Name

Alshareef

MiddleName

A.

Affiliation

Microbiology and Immunology Department, Faculty of Pharmacy, October 6 University, Giza, Egypt

Email

dr.walaa@o6u.edu.eg

City

-

Orcid

0000-0003-3487-9044

First Name

Heba

Last Name

El Gizawy

MiddleName

A.

Affiliation

Pharmacognosy Department, Faculty of Pharmacy, October 6 University, Giza, Egypt.

Email

hebaelgizawy62@gmail.com

City

-

Orcid

0000-0002-1543-8844

Volume

65

Article Issue

10

Related Issue

34864

Issue Date

2022-10-01

Receive Date

2022-01-16

Publish Date

2022-10-01

Page Start

279

Page End

284

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 10_Pages 279-284.pdf

PDF . 328.1kB

Link

https://ejchem.journals.ekb.eg/article_221194.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=221194

Order

26

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Comparative characterization of carob pulp and seeds extracts: HPLC, antimicrobial, anti-inflammatory, and cytotoxic studies

Details

Type

Article

Created At

22 Jan 2023