243437

Metabolic Pathway of Resistant Starch via Micro Biome in Healthy and Hyperglycemic Rats

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Biochemistry

Abstract

Google engines claimed that green banana is a miracle fruit, is this true?

Green banana powder (GBP) was given to diabetic and healthy rats in two different concentrations to see how it affected them. The goal of the planned study was to see how GBP feeding affected diabetic rats. Method: Sixty male albino rats were separated into six groups: the control group was fed a standard diet, while the GV and G VI groups were given 5 and 2.5 percent of a GBP diet, respectively, to assess their safety. To induce diabetes, GII was given an intraperitoneal "IP" injection of streptozotocin (STZ) (40 mg/kg BW). For 30 days, GIII and G IV diabetic rats were given 5 and 2.5 % of the GBP diet, respectively. Rats were exposed to biological evaluation measures throughout the investigation (feed intake, growth curve). Biochemical assays (serum diabetes markers, liver functions; GSH and MDA as antioxidants indication in liver tissue) and histopathological characteristics of the liver and pancreas were performed at the end of the treatment period. Finally, the results showed that the GBP had no physiological deleterious effects in healthy rats throughout the research except for around 20% of the rats, who showed some histopathological alterations after consuming a 5% GBP. From biological and biochemical parameters, treatment with 2.5 % GBP alleviated STZ-induced diabetes more than treatment with 5 % GBP. Conclusion: GBP contains high-resistance starch, which promotes a healthy gut microbiome, and bioactive composites that have a beneficial impact on diabetes via antioxidants and anti-inflammatory effects when consumed in safe doses to avoid negative impacts. Recommendation: Consuming little amounts of green banana for short times may be more useful and safer in terms of diabetes management.

DOI

10.21608/ejchem.2022.133988.6034

Keywords

Keywords: Green Banana, resistant starch, Hyperglycemia in rats

Authors

First Name

Salwa

Last Name

El-Magoli

MiddleName

-

Affiliation

Food science department, Faculty of Agriculture, Cairo Giza 12613, Egypt

Email

dodoagro@agr.cu.edu.eg

City

Cairo

Orcid

-

First Name

Hanaa

Last Name

Hamad

MiddleName

Hussein

Affiliation

National institute for nutrition

Email

hanaa_hamad2003@yahoo.com

City

Cairo

Orcid

0003-0443-0940

First Name

Shahira

Last Name

Al-Gamal

MiddleName

Asem

Affiliation

Food science department, National Nutrition Institute, Cairo, Egypt and Food science department, Faculty of Agriculture, Cairo Giza 12613, Egypt

Email

algamal.shahira@gmail.com

City

Cairo

Orcid

-

First Name

Mohamed E

Last Name

Abdel-Aziz

MiddleName

-

Affiliation

Food Science Department, Faculty of Agriculture, Cairo University, Giza 12613, Egypt

Email

dodoagro@gmail.com

City

Giza

Orcid

-

Volume

65

Article Issue

10

Related Issue

34864

Issue Date

2022-10-01

Receive Date

2022-05-03

Publish Date

2022-10-01

Page Start

1

Page End

16

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_243437.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=243437

Order

1

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Metabolic Pathway of Resistant Starch via Micro Biome in Healthy and Hyperglycemic Rats

Details

Type

Article

Created At

22 Jan 2023