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241734

Ibuprofen amino acid derivatives: synthesis, docking and biological studies

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Organic chemistry

Abstract

This work aimed to synthesize new Ibuprofen amino acid derivatives as safe non-steroidal anti-inflammatory drugs (NSAIDs). The structures of the synthesized compounds have been determined using various spectral data. For tested compounds , molecular docking was performed into the cyclooxygnase-2 (COX-2) active site. The lowest root-mean-square deviation of atomic positions (RMSD) pose has been chosen for the binding affinity discussion. Docking protocol revealed that the binding interaction increased by the presence of hydrazide fragment in the tested compounds. Passed compounds through docking profile were examined for their anti -inflammatory and analgesic activities. Using a carrageenan-induced mouse model of hind paw edoema, we investigated the potential anti-inflammatory efficacy of the synthetic compounds in comparison to their parent molecule, ibuprofen. In addition to assessing the antinociceptive and ulcerogenic properties of the synthesized compounds

DOI

10.21608/ejchem.2022.130671.5755

Keywords

NSAIDs, Peptide candidates, Anti-inflammatory and Analgesic agents, docking

Authors

First Name

AbdelHameed

Last Name

Selim

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Al-Azhar University (Boys' Branch), Nasr City, Cairo, Egypt

Email

aselemfue@gamil.com

City

-

Orcid

-

First Name

Ewies

Last Name

Fawzy

MiddleName

-

Affiliation

Organometallic and Organometalloid Chemistry, Chemical Industries Research Institute, National Research Centre

Email

ewiesfawzy@yahoo.com

City

Giza

Orcid

0000-0002-4832-5766

First Name

Reem

Last Name

Attia

MiddleName

T

Affiliation

Department of Pharmacology, Toxicology and Biochemistry, Future University in Egypt, Cairo, Egypt.

Email

reem.tarek@fue.edu.eg

City

Cairo

Orcid

-

First Name

Said

Last Name

Shedid

MiddleName

M.

Affiliation

Chemistry Department, Faculty of Science, Al-Azhar University (Boys' Branch), Nasr City, Cairo, Egypt

Email

shedid@gmail.com

City

Cairo

Orcid

-

First Name

Mohamed

Last Name

El-Gazzar

MiddleName

A

Affiliation

Chemistry Department, Faculty of Science, Al-Azhar University (Boys' Branch), Nasr City, Cairo, Egypt

Email

elgazzarm@gmail.com

City

Cairo

Orcid

-

Volume

65

Article Issue

9

Related Issue

31876

Issue Date

2022-09-01

Receive Date

2022-03-30

Publish Date

2022-09-01

Page Start

749

Page End

761

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 9_Pages 749-761.pdf

PDF . 811.3kB

Link

https://ejchem.journals.ekb.eg/article_241734.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=241734

Order

68

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Ibuprofen amino acid derivatives: synthesis, docking and biological studies

Details

Type

Article

Created At

22 Jan 2023