The present paper analyzes the influences of entropy generation as well as slip velocity and temperature conditions on MHD micropolar biviscosity nanofluid flow through a porous medium in a channel with peristalsis. The fluid effects of mixed convection, radiation, viscous dissipation and thermal micropolar properties are taken into consideration. The assumptions of low-Reynolds number and long-wavelength are used to simplify the governing equations of this problem. A semi-analytical solutions of these equations are obtained by using homotopy perturbation method. Moreover, the entropy generation is obtained in this study. Results are discussed for various parameters of the problem and depicted graphically. Physically, our model is consistent with the motion of digestive juice in the bowel whenever we are going to insert an endoscopy through it.