This study aimed to increase tomato productivity through improving fruit set and plant performance and its chemical contents using plant growth regulators. A specific experiment has been carried out to study the effect of plant growth regulators: Milagro (1% indole-3-butric acid) and Atlet active substances (4% chloromequate chloride plus 0.01% indole-3-butric acid) at different three applied doses: 0.6, 1.0 and 1.5 M/L and 1.0, 1.5 and 2.0 M/L, respectively on growth and chemical composition of tomato plants (Big bif F1). Both growth regulators were foliar applied three times spraying on plants at 30, 60 and 90 days after transplanting (DAT). The obtained results showed that foliar application of Milagro at 1.0 M/L resulted in the highest significant number of leaves per plant and leaf area at 30, 60 and 90 DAT, as well as number of flower cluster per plant and increased fruit number per plant and fruit weight during the cultivated seasons. The foliar application of Atlet at 1.5 M/L increased plant height and stem diameter at 30, 60 and 90 DAT during the cultivated seasons. Chlorophyll contents in leaves was increased by foliar application of Atlet at 1.5 and 2.0 M/L during the first and second growing seasons, respectively. Milagro significantly improved tomato fruit quality by increasing total soluble solid (TSS), vitamin C and carotenoids contents in tomato fruits. While, Atlet at 1.5 M/L increased dry matter percent in tomato fruits.