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214941

Zinc oxide nanoparticles characterization and therapeutic evaluation on high fat / sucrose diet induced-obesity

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Inorganic chemistry

Abstract

ZnO/KCl nanocomposite was prepared by solgel to appreciate the role of synthesized ZnO-NPs to curb obesity in a high-fat diet rat model. KCl played an important role in decreasing the particle size (30 nm) and also in facilitating the suspension formation of ZnO-NPs. XRD and HRTEM were carried out to estimate the particle size while SEM was used to investigate the morphology of the nanoparticles. XPS measurements were used to examine the chemical compositions of the nanocomposite. XRD declared that ZnO has a hexagonal wurtzite structure. The Rietveld refinement has also been executed (chi2 = 1.0 and R-factor was 0.05). The treatment of obese rats with ZnO-NPs enhanced the adiponectin level, hepatic carnitine (Car) and reduced hepatic glutathione (GSH) with lowering the liver enzymes and pathological changes. The treatment coused a decrease in body weight gain, Body mass index (BMI), leptin level, cholesterol, triglycerides, glucose, immunohistochemistry for nuclear factor kappa (NFκB), the insulin resistance index (HOMA-IR) and a reduction in hepatic malondialdehyde (MDA), nitric oxide (NO), and 8-Hydroxy-2'-deoxyguanosine (8OHdG). The results indicated a positive correlation between BMI and oxidative stress parameters. In conclusion, ZnO-NPs manifested valuable anti-obesity effects via lowering body weight gain, oxidative stress, BMI, lipids, and insulin resistance.

DOI

10.21608/ejchem.2022.112166.5113

Keywords

ZnO-NPs, Rietveld analysis, Obesity, Metabolic syndrome, inflammatory markers, Oxidative Stress

Authors

First Name

Ahmed M. A.

Last Name

El-Seidy

MiddleName

-

Affiliation

Inorganic Chemistry Department، National Research Centre, 33 El ‐Bohouth St., P.O. 12622, Dokki, Cairo, Egypt.

Email

ahmedmaee2@gmail.com

City

شبين الکوم

Orcid

0000-0003-0708-7658

First Name

Samir

Last Name

Bashandy

MiddleName

A.

Affiliation

Pharmacology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El- Bohouth St., Dokki, P.O. 12622, Cairo, Egypt

Email

bashandysamir@gmail.com

City

-

Orcid

-

First Name

Fatma

Last Name

Ibrahim

MiddleName

A. A.

Affiliation

Biochemistry Dept, Biotechnology Institute, National Research Centre, 33 EL BohouthSt., Dokki, Cairo, Egypt

Email

fatmaibrahim2020@gmail.com

City

-

Orcid

-

First Name

Sahar

Last Name

Abd El-Rahman

MiddleName

S.

Affiliation

Pathology Dept, Faculty of Veterinary Medicine, Cairo University,

Email

saharsamirmah@cu.edu.eg

City

-

Orcid

-

First Name

Omar

Last Name

Farid

MiddleName

-

Affiliation

Researcher, National organization of drug control and research

Email

ebntaimya@yahoo.com

City

-

Orcid

-

First Name

Sherif

Last Name

Moussa

MiddleName

-

Affiliation

Biochemistry Dept, Biotechnology Institute, National Research Centre, 33 EL BohouthSt., Dokki, Cairo, Egypt

Email

sherifmoussa96@gmail.com

City

-

Orcid

0000-0002-4553-3842

First Name

Marwan

Last Name

El-Baset

MiddleName

A.

Affiliation

Pharmacology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El- Bohouth St., Dokki, P.O. 12622, Cairo, Egypt

Email

dr.marawan@gmail.com

City

-

Orcid

0000-0002-0861-6251

Volume

65

Article Issue

9

Related Issue

31876

Issue Date

2022-09-01

Receive Date

2021-12-23

Publish Date

2022-09-01

Page Start

497

Page End

511

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 9_Pages 497-511.pdf

PDF . 1.0MB

Link

https://ejchem.journals.ekb.eg/article_214941.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=214941

Order

47

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Zinc oxide nanoparticles characterization and therapeutic evaluation on high fat / sucrose diet induced-obesity

Details

Type

Article

Created At

22 Jan 2023