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216736

Synthesis and Characterization of Novel Isoxazolidine-Thiosemicarbazone Hybrid Derivatives as Precursor of Unnatural Amino acids

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

Novel sixteen enantiopure isoxazolidine-(thio)semicarbazone hybrid derivatives were synthesized by condensation of isoxazolidines based on benzaldehyde derivatives with (thio)semicarbazide in good yield. The analysis of the 1D NMR and NOESY spectra of all compounds unambiguously confirms the E-stereochemistry of the synthesized (thio)semicarbazones.

DOI

10.21608/ejchem.2022.111980.5088

Keywords

isoxazolidine, Semicarbazone, Thiosemicarbazone, enantiopure, Stereochemistry

Authors

First Name

snoussi

Last Name

mejdi

MiddleName

-

Affiliation

University of Monastir

Email

snmejdi@gmail.com

City

-

Orcid

-

First Name

Ameni

Last Name

Ghabi

MiddleName

-

Affiliation

University of Monastir

Email

amenigh44@yahoo.com

City

-

Orcid

-

First Name

jihed

Last Name

brahmi

MiddleName

-

Affiliation

university of monastir

Email

jihedbrahmi85@live.fr

City

-

Orcid

-

First Name

Adel

Last Name

Kadri

MiddleName

-

Affiliation

Faculty of Science of Sfax, Department of Chemistry, University of Sfax, B.P. 1171, 3000 Sfax, Tunisia.

Email

lukadel@yahoo.fr

City

-

Orcid

-

First Name

Kais

Last Name

Aouadi

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Qassim University, buraidah

Email

kaiss_aouadi@hotmail.com

City

-

Orcid

-

Volume

65

Article Issue

9

Related Issue

31876

Issue Date

2022-09-01

Receive Date

2021-12-19

Publish Date

2022-09-01

Page Start

439

Page End

447

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 9_Pages 439-447.pdf

PDF . 770.7kB

Link

https://ejchem.journals.ekb.eg/article_216736.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=216736

Order

42

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Synthesis and Characterization of Novel Isoxazolidine-Thiosemicarbazone Hybrid Derivatives as Precursor of Unnatural Amino acids

Details

Type

Article

Created At

22 Jan 2023