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215446

Synthesis and In-vitro Biological Analyses of New quinazolin-2,4-dione Derivatives

Article

Last updated: 22 Jan 2023

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-

Tags

Pharmaceutical Chemistry

Abstract

A series of quinazolin-2,4-dione analogues (1-17a,b) were prepared and their chemical structures were confirmed using spectral and microanalytical data. Analysis of the in vitro cytotoxic effect of the synthesized compounds using RBCs toxicity assay was achieved. Also, biological screening on their potential anticancer effect on hepatocellular carcinoma cell line (HepG2) and their antimicrobial activity against three microbes (bacteria, yeast, and fungus) was studied. Only two compounds 5 and 17b had a moderate anti-HCC activity with calculated IC50 equals 382.9±6.9 µg/ml and 415.8±3.8 µg/ml, respectively. Compound 9 had the highest anti-Aspergillus niger effect, compound 5 had the highest anti-Candida albicans effect, compound 6 had the highest anti-Staphylococcus aureus effect, and compound

DOI

10.21608/ejchem.2022.111820.5077

Keywords

Quinazolin-2, 4-diones, HCC, RBCs toxicity, antimicrobia

Authors

First Name

H.R.M.

Last Name

Rashdan

MiddleName

-

Affiliation

Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Institute, Dokki, Cairo 12622, Egypt.

Email

hudadawoud20@yahoo.com

City

-

Orcid

0000-0001-7474-1678

First Name

H.

Last Name

Okasha

MiddleName

-

Affiliation

Biochemistry and Molecular Biology Department, Theodor Bilharz Research Institute, Giza, Egypt.

Email

hend.oaa@gmail.com

City

-

Orcid

0000-0003-1125-245X

First Name

M. A.

Last Name

Abdelhakeem

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, South Valley University, 83523 Qena, Egypt.

Email

-

City

-

Orcid

-

First Name

A. M.

Last Name

Mosallam

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, South Valley University, 83523 Qena, Egypt.

Email

-

City

-

Orcid

-

First Name

H.

Last Name

Temairk

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, South Valley University, 83523 Qena, Egypt.

Email

-

City

-

Orcid

-

First Name

A.G.

Last Name

Alhamzani

MiddleName

-

Affiliation

Chemistry Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia.

Email

-

City

-

Orcid

-

First Name

M.M.

Last Name

Abou-Krisha

MiddleName

-

Affiliation

Biochemistry and Molecular Biology Department, Theodor Bilharz Research Institute, Giza, Egypt., Chemistry Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia.

Email

mmaboukrisha@imamu.edu.sa

City

-

Orcid

-

First Name

T.A.

Last Name

yousef

MiddleName

-

Affiliation

Biochemistry and Molecular Biology Department, Theodor Bilharz Research Institute, Giza, Egypt., Department of Toxic and Narcotic drug, Forensic Medicine, Mansoura Laboratory, Medicolegal organization, Ministry of Justice, Egypt.

Email

tayousef@imamu.edu.sa

City

-

Orcid

-

First Name

A.H.

Last Name

Abdelmonsef

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, South Valley University, 83523 Qena, Egypt.

Email

aboubakr.ahmed@sci.svu.edu.eg

City

Qena

Orcid

0000-0002-4616-0224

Volume

65

Article Issue

9

Related Issue

31876

Issue Date

2022-09-01

Receive Date

2021-12-18

Publish Date

2022-09-01

Page Start

189

Page End

199

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 9_Pages 189-199.pdf

PDF . 597.4kB

Link

https://ejchem.journals.ekb.eg/article_215446.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=215446

Order

18

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023