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215703

Cartilage Oligomeric Matrix Protein As A Serological Biomarker for the Assessment of Liver Fibrosis Before and After Treatment of HCV Infection

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Biochemistry

Abstract

The goal of this study was to determine cartilage oligomeric matrix protein (COMP) levels as a biochemical marker in various phases of hepatic fibrosis and to estimate its effectiveness for hepatic fibrosis monitoring. Eighty-eight patients with various stages of hepatic fibrosis were enrolled in this trial, all of whom had a sustained virological response after using direct-acting antivirals. Patients were followed-up after one year of treatment. FibroScan and COMP were determined before and after one year from the end of treatment. Liver enzymes such as alanine transaminase, aspartate transaminase, and alkaline phosphatase were measured in addition to albumin, total bilirubin, creatinine, and glucose. COMP levels increased with the progression of liver fibrosis, according to our findings. COMP enabled the correct identification of F2-F4, F3-F4 and F4 with areas under the curve of 0.765, 0.788 and 0.790, respectively. Our findings showed that 68.4%, 87.1%, and 98.6% of F4, F3-F4, and F4, respectively, were positive for COMP. Notably, the vast majority of individuals who tested positive for COMP were appropriately classified. In conclusion, this work provides a promising marker that might be used as a potential serologic biomarker for liver fibrosis staging and may facilitate definitive therapy as well as a complementary diagnostic tool in monitoring cirrhotic patients for detection of early HCC.

DOI

10.21608/ejchem.2022.109105.4994

Keywords

Liver fibrosis, Cirrhosis, COMP, Liver enzymes, Diagnosis

Authors

First Name

Abdallah

Last Name

Ragab

MiddleName

A.

Affiliation

Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt

Email

lab_almadina1@yahoo.com

City

-

Orcid

-

First Name

Sanaa

Last Name

Abdallah

MiddleName

O.

Affiliation

Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt

Email

sanaa.osman.aa@gmail.com

City

-

Orcid

-

First Name

Gamal

Last Name

Shiha

MiddleName

-

Affiliation

Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt

Email

g-shiha@hotmail.com

City

-

Orcid

-

First Name

Hisham

Last Name

Ismail

MiddleName

-

Affiliation

Biochemistry department, Faculty of Science, Minia University

Email

himosman@hotmail.com

City

-

Orcid

0000-0002-7593-4532

First Name

Mohamed

Last Name

Albnnan

MiddleName

S.

Affiliation

Biotechnology Research Center, New Dameitta 34517, Egypt

Email

mohamedalbannan@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

El-Desouky

MiddleName

Aly

Affiliation

Biochemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt

Email

ma.des38@yahoo.com

City

-

Orcid

0000-0001-5007-5455

Volume

65

Article Issue

9

Related Issue

31876

Issue Date

2022-09-01

Receive Date

2021-12-05

Publish Date

2022-09-01

Page Start

93

Page End

98

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_215703.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=215703

Order

9

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Cartilage Oligomeric Matrix Protein As A Serological Biomarker for the Assessment of Liver Fibrosis Before and After Treatment of HCV Infection

Details

Type

Article

Created At

22 Jan 2023