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Study the mammalian acute toxicity of sodium yttrium fluoride, erbium and ytterbium doped (NaYF4: Er3+, Yb3+) upconversion nanomaterials

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Biochemistry

Abstract

The potential toxicity and biocompatibility of sodium yttrium fluoride, erbium and ytterbium doped (NaYF4: Er3+, Yb3+) upconversion nanoparticles are of great importance for their biomedical applications. In this work, the acute toxicity of sodium yttrium fluoride, erbium and ytterbium doped (NaYF4: Er3+, Yb3+) upconversion nanomaterials toxicity was evaluated. Rats received intravenous injection of 10 mg/kg of NaYF4: Er3+, Yb3+ doped upconversion nanoparticles once dose and were observed at two different times (24 hours and 14 days post injection) for acute toxicity compared with control group. The results of hematological, blood biochemical analyses indicated that NaYF4: Er3+, Yb3+ doped upconversion nanoparticles treated rats survived for 14 days without any evident of toxic effects. Histopathological analysis of major organs including liver had no obvious signs of abnormality after intravenous injection of rats by NaYF4: Er3+, Yb3+ doped upconversion nanoparticles.

DOI

10.21608/ejchem.2022.121196.5481

Keywords

NaYF4: Er3+, Yb3+ doped upconversion nanoparticles & acute toxicity

Authors

First Name

Mohamed

Last Name

Shahba

MiddleName

-

Affiliation

Medical Biochemistry, National Research Centre, Cairo, Egypt

Email

shahbamohamed@yahoo.com

City

-

Orcid

-

First Name

Zakaria

Last Name

El-Khyat

MiddleName

-

Affiliation

Clinical Biochemistry, National Research Center, Egypt

Email

zkkh200000@yahoo.com

City

-

Orcid

-

First Name

Maha

Last Name

El-Wassef

MiddleName

M.

Affiliation

Medical Biochemistry Department, National Research Centre, Egypt

Email

mahaelwassefe@yahoo.com

City

-

Orcid

-

First Name

Mahmoud

Last Name

Sliem

MiddleName

A.

Affiliation

Department of Laser application in photochemistry and photobiology, National Institute of Laser Enhanced Sciences, Cairo University, Egypt.

Email

mahmoud.ashour@rub.de

City

-

Orcid

-

First Name

Omar

Last Name

Farid

MiddleName

-

Affiliation

Researcher, National organization of drug control and research

Email

ebntaimya@yahoo.com

City

-

Orcid

-

First Name

Tarek

Last Name

El-Tayeb

MiddleName

A.

Affiliation

Department of Laser application in photochemistry and photobiology, National Institute of Laser Enhanced Sciences Cairo University, Egypt.

Email

hasb1972@yahoo.com

City

-

Orcid

-

Volume

65

Article Issue

8

Related Issue

31862

Issue Date

2022-08-01

Receive Date

2022-02-18

Publish Date

2022-08-01

Page Start

699

Page End

705

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 8_Pages 699-705.pdf

PDF . 363.0kB

Link

https://ejchem.journals.ekb.eg/article_222299.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=222299

Order

62

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Study the mammalian acute toxicity of sodium yttrium fluoride, erbium and ytterbium doped (NaYF4: Er3+, Yb3+) upconversion nanomaterials

Details

Type

Article

Created At

22 Jan 2023