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209037

Synthesis, Cytotoxic, and Apoptotic Activity of New N-(Arylglycyl)succinohydrazide and their Sugar Hydrazone Derivatives

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

Hydrazones have pronounced properties that allow them promising for a range of synthetic applications. In the current study, new acid hydrazide compounds incorporating substituted arylglyl and succinyl moieties were prepared via multistep process including formation of the corresponding acid compounds followed by formation of the derived esters and hydrazinloysis reactions. The synthesized acylhydraizdes were used for the preparation of novel functionalized sugar hydrazones and their derived per-O-acetylated derivatives. The hydrazones and their acetylated analogs were studied for their cytotoxic activity against hepatic HCT116 and HepG2 and MCF7 breast cancer cell lines and it was revealed that hydrazones 16, 17 and 18 possessing per-O-acetylated sugar moieties showed high cytotoxic activity compared to the reference drug.

DOI

10.21608/ejchem.2021.106807.4902

Keywords

arylglycyl, hydrazides, sugar hydrazone, Cytotoxicity, Anticancer

Authors

First Name

Wael A.

Last Name

El-Sayed

MiddleName

-

Affiliation

Photochemistry Department, National Research Centre, Dokki, Giza 12622 Egypt, Department of Chemistry, College of Science, Qassim University, Buraidah, 51452 Saudi Arabia

Email

waelshendy@gmail.com

City

-

Orcid

-

First Name

Hussein H.

Last Name

Elganzory

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Qassim University, Buraidah, 51452 Saudi Arabia

Email

hhsien@qu.edu.sa

City

Buraidah

Orcid

0000-0002-9426-5434

First Name

Abeer S. A.

Last Name

Khalaf-Allaha

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom ,Egypt.

Email

abeerahmed222.com@gmail.com

City

-

Orcid

-

First Name

Ashraf M.

Last Name

Mohamed

MiddleName

-

Affiliation

Applied Organic Chemistry Department, National Research Centre, Dokki, Giza 12622 Egypt,

Email

ammewas1@gmail.com

City

Giza

Orcid

0000-0001-7019-5286

First Name

Ahmed A.

Last Name

Abd-Rabou

MiddleName

-

Affiliation

Hormones Department, Medicine and Clinical Studies Research Institute, & Stem Cells Lab, Center of Excellence for Advanced Sciences, National Research Center, Dokki 12622, Giza, Egypt.

Email

ahmedchemia87@yahoo.uk

City

-

Orcid

-

First Name

Yasser Kamal

Last Name

Abdel-Monem

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom ,Egypt.

Email

ykabdelmonem@gmail.com

City

Shebin El-Kom

Orcid

-

Volume

65

Article Issue

7

Related Issue

31861

Issue Date

2022-07-01

Receive Date

2021-11-18

Publish Date

2022-07-01

Page Start

567

Page End

576

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 7_Pages 567-576.pdf

PDF . 563.3kB

Link

https://ejchem.journals.ekb.eg/article_209037.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=209037

Order

56

Type

Review Articles

Type Code

444

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Synthesis, Cytotoxic, and Apoptotic Activity of New N-(Arylglycyl)succinohydrazide and their Sugar Hydrazone Derivatives

Details

Type

Article

Created At

22 Jan 2023