The aim of this study is to determine the bioactive compounds in M. indica peels extract which act as bioreducer agent with aqueous silver nitrate solution (AgNO3) which act as precursor at different conditions. The phytoconstituents in the peels acted as reducing and stabilizing agent for Silver Nanoparticles (AgNPs) formation. UV-Vis spectroscopy, analysis were used to characterize the green synthesized AgNPs showed characteristic spectra at 430 nm. The size of the synthesized AgNPs is in the range from 1.5 to 9.5 nm, with an average size of 6.5 nm. SEM images showed that the green synthesized silver nanoparticles have a relatively spherical shape with a diameter of 38-62 nm. In addition, M. indica Peels extract and AgNPs showed efficient cytotoxic activities against (MCF-7) breast carcinoma cell line and (HeLa) cervical carcinoma cell line in comparison to Doxorubicin drug. The anticancer activity of AgNPs may be due to the number of phenolic compounds which was carried on the surface of silver nanoparticles. The results showed that synthesized AgNPs decreased % cell viability against MCF-7 and HeLa cell lines.