‎ Diabesity, a combined diabetes and obesity, is a worldwide illness in the 21 century. The aim of the present research was ‎to study blood glucose, lipid profile, iron status, immune system and cardiac and hepatic pathology in diabesity rat model ‎and the potential protection by neutraceuticals. Dietary obesity and diabetes were simultaneously induced in rats as model of ‎diabesity. Three nutraceuticals were tested (Lepidium sativum seed ethanol and water extracts and Boswellia carterii water ‎extract). Biochemical analysis of blood and histopathological examination of liver and heart were carried out. Phenolic and ‎flavonoidal contents were determined in Lepidium sativum seed and Boswellia carterii. Results showed iron deficiency, ‎dyslipidemia and significantly elevated interleukin 6, blood glucose and malondialdehyde, in addition to alteration in the ‎histopathology of liver and heart in the diabesity control (DOC) group compared to the NC group. Treatment with the ‎different nutraceuticals produced variable improvement compared to the DOC group. Lepidium sativum seed showed higher ‎phenolic and flavonoidal contents than Boswellia carterii (p ≤ 0.05). Lepidium sativum ethanol extract was superior in ‎improving dyslipidemia, inflammation and oxidative stress while Boswellia carterii water extract was the most anti-‎hyperglycemic. Lepidium sativum seed water extract showed the best improvement in iron status.‎