The activity of Ridomil gold plus, Cassia nodosa extract, bio silica NPs and chem silica NPs investigated against Fusarium. oxysporum and Rhizoctonia solani. The results indicated that all tested compounds decreased the growth of F. oxysporum and R. solani with increased concentrations. F. oxysporum more sensitive to all tested compounds except chem silica NPs. The fungicide Ridomil is the most effective against both fungi followed by C. nodosa extract and bio silica NPs. In contrast, the chem silica NPs less effective in inhibiting the growth of F. oxysporum and R. solani. The fungicide Ridomil at 1000 ppm resulted in the emergence of irregular and unstable forms in fragments. The use of C. nodosa extract at 2100 ppm led to the appearance of deformations and degradation of the fragile filaments. While there was clear decomposition and deformation in the fragments from the use of bio silica NPs in the microscopic field of 400, these distortions increased in the magnified field 1000x with the presence of lacunae in the hypo filaments of both F. oxysporum and R. solani.