Nanoporous metal-organic frameworks (MOFs) are three-dimensional porous lattices of inorganic-organic linkers. These materials have tunable physiochemical properties such as high porosity, crystalline nature, chemical, thermal and mechanical stability as well. 2-Amino-1,4-benzenedicarboxylic acid plays an important role in metal-organic frameworks synthesis and post-synthetic modification. It reacts with different metals such as: 3d-transition metal (Zn, Co, Cu, Mn, and Fe), 4d-transition metal (Cd, Ag, and Y), s-alkaline metal (Ca), p- metal (Sn and Al) and 4f-lanthanids (Er, La, Dy, Tb, Nd, Yb, Eu, Pr, Gd and Sm) to produce MOFs with different structures. The second-biggest application of 2-amino-1,4-benzenedicarboxylic in MOFs is post-synthetic modification because of the presence of the amino group, such as: IRMOF-3, DMOF-1-NH2, UMCM-1-NH2, MOF-LIC-1, MIL-53-NH2, UIO-66-NH2, MIL-101-NH2. This functionalized MOFs react with different organic reagents to produce new MOFs with new applications fields such as gas separation, catalysis, gas storage, water treatment, and other different applications.