Acute Myocardial Infarction (AMI) is still most caused by plaque rupture. ST-segment elevation Myocardial Infarction (STEMI) and non-ST-segment elevation Myocardial Infarction (NSTEMI) are two types of AMI that have distinct clinical characteristics. Several studies have found a strong association between Myeloperoxidase (MPO) and a wide range of AMI. MPO – 463 is a frequent MPO single nucleotide polymorphism (SNP) that has a G to A mutation at position 463 bp. Meanwhile, another SNP, MPO-129, is found in the MPO gene promoter. To our knowledge, this is the first study to investigate the association between MPO -463 and MPO -129 with patient survival in an IRAQI population. This study aimed to evaluate two single nucleotide polymorphisms (SNPs) frequency in MPO gene of Iraqi patients with AMI in comparison with control and the association between polymorphisms of these SNPs and the Incidence of AMI in Iraqi patients. The outcomes demonstrated that three different genotypes are found by genotyping the MPO genes (-463) & (-129). They are GG genotype, AG genotype, and AA genotype. The AG genotype of MPO-463 and MPO-129 may be considered as a risk factor in the clinical condition of non-ST-segment elevation Myocardial Infarction (NSTEMI) and ST-segment elevation myocardial Infarction (STEMI .