Background: Serious intense respiratory disorder Covid-19 is a causing respiratory infection known as Corona virus. This novel corona virus transmits from one human to another and has caused significant mortality overall prompting the continuous pandemic. Also, illness seriousness varies extensively from one person to another. Subjects: fifty individuals (n = 50) with age ranged (20-65 years) were enrolled in this study. Laboratory parameters were performed of baseline and 14 days after first dose and 14 days after second dose from covid-19 vaccination. Results: All people in this study received the Pfizer-BioNTech vaccine and none systematic side effects were observed in vaccinated subjects during the study period. Conclusions: From the results of present study, conclusions could be that all parameters non-significant and not presence of abnormal biochemical signs or increase in coagulation or changes in basic body functions following the received of the Pfizer vaccine.