In recent years a great attention has been focused on preparing highly efficient, cheaper and ecofriendly adsorbents which used for heavy metals removal from wastewater. This work deals with the use of sugarcane bagasse (SCB) adsorbent for removal of Fe (III), Mn (II) and Pb (II). SEM and FTIR spectroscopy were used for characterization of the prepared adsorbent. Also the adsorption effects under different conditions of pH, adsorbent weight, initial metal concentrations, contact time and temperature on the percent of heavy metals removal were investigated. Adsorption isotherm investigation indicated that, Fe metal was fitted to Temkin model, where Mn and Pb metals were fitted to the Freundlich model. The study of thermodynamic parameters showed that, the negative values of ΔG° indicated that the adsorption of (Fe, Mn and Pb) on SCB is a spontaneous process.