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195930

Some 3,4,5-Trisubstituted-1,2,4-triazole Synthesis, Antimicrobial Activity, and Molecular Docking Studies

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Organic chemistry

Abstract

Methyl 4-aminopicolinate 1 interacted with hydrazine hydrate and subsequently with carbon disulfide to produce a triazole thiol derivative, which then reacted with different aldehydes to produce the appropriate Schiff base products. 4a-c. The reaction of Schiff base products 4a-c with benzoyl chloride resulted in the formation of trisubstituted triazoles 5a-c. The spectroscopic studies of the produced chemicals helped to clarify their structures. The antibacterial activity of the produced compounds against various bacterial and fungal strains was tested. Molecular docking studies of newly synthesized 1,2,4-triazoles were also conducted.

DOI

10.21608/ejchem.2021.93025.4397

Keywords

triazole, Schiff base, Molecular docking, antimicrobial activity

Authors

First Name

Ahmed

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq.

Email

ahmed.ahmed@gmail.com

City

-

Orcid

-

First Name

Ismaeel

Last Name

Majeed

MiddleName

Y.

Affiliation

Department of Chemistry, College of Education for Pure Science Ibn-Al-Haitham, University of Baghdad, Iraq

Email

ranaalrefai682@gmail.com

City

-

Orcid

-

First Name

Noora

Last Name

Asaad

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq.

Email

noora.asaad@gmail.com

City

-

Orcid

-

First Name

Riyadh

Last Name

Ahmed

MiddleName

Mahmood

Affiliation

Department of Chemistry, College of Education for Pure Science Ibn-Al-Haitham, University of Baghdad, Iraq.

Email

riyadh.mahmood.ahmed@gmail.com

City

-

Orcid

-

First Name

Ghada

Last Name

Kamil

MiddleName

M.

Affiliation

Department Of Applied sciences, Branch of Applied Chemistry, University Of Technology, Baghdad, Iraq.

Email

ghadam.kamil@gmail.com

City

-

Orcid

-

First Name

Sarah

Last Name

Abdul Rahman

MiddleName

-

Affiliation

Department of Chemistry, College of Education for Pure Science Ibn-Al-Haitham, University of Baghdad, Iraq.

Email

sarah.abdul.rahman@gmail.com

City

-

Orcid

-

Volume

65

Article Issue

3

Related Issue

29682

Issue Date

2022-03-01

Receive Date

2021-08-28

Publish Date

2022-03-01

Page Start

395

Page End

401

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 3_Pages 395-401.pdf

PDF . 891.0kB

Link

https://ejchem.journals.ekb.eg/article_195930.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=195930

Order

37

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Some 3,4,5-Trisubstituted-1,2,4-triazole Synthesis, Antimicrobial Activity, and Molecular Docking Studies

Details

Type

Article

Created At

22 Jan 2023