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197636

Isolation and Characterization of Stigmasterol and β-sitosterol from Plectranthus scutellarioides var. color blaze dark star and Cytotoxicity of Its Fraction

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Pharmaceutical Chemistry

Abstract

Plectranthus scutellarioides is one of medicinal plants in Indonesia, traditionally known as iler/miana/jawer kotok. Due to a large number of varieties, certain varieties of P. scutellarioides have not been extensively studied. This study focused on the isolations of two phytosterols, stigmasterol and β-sitosterol, which were characterized by various 1D and 2D NMR analyses, from the ethyl acetate extract of P. scutellarioides var. color blaze dark star. Cytotoxicity of the ethyl acetate extract and some selected fractions were evaluated against A549, MDA-MB-231, MCF-7, KB, and KB-Vin cell lines using SRB (Sulforhodamine B) method. Among all tested sample, fractions 15 and 17 have significantly inhibited cell growth with IC50 of 14.3-24.3 µg/mL and 7.3-14.1 µg/mL, respectively.

DOI

10.21608/ejchem.2021.80171.3972

Keywords

Plectranthus scutellarioides, Stigmasterol, β-sitosterol, Cytotoxicity

Authors

First Name

Ayun

Last Name

Astuti

MiddleName

Dwi

Affiliation

Department of Medical Science, Faculty of Medicine, Hasanuddin University, Makassar 90245, Indonesia

Email

aayundwi@gmail.com

City

-

Orcid

0000-0003-2784-9883

First Name

Budiman

Last Name

Yasir

MiddleName

-

Affiliation

Faculty of Medicine, Hasanuddin University, Makassar 90245, Indonesia

Email

budimanyasir12@gmail.com

City

Makassar

Orcid

0000-0002-1976-8138

First Name

Abdul

Last Name

Rahim

MiddleName

-

Affiliation

Department of Pharmacognosy-Phytochemistry, Faculty of Pharmacy, Hasanuddin University, Makassar 90245, Indonesia

Email

abdulrahim@unhas.ac.id

City

-

Orcid

0000-0003-1409-7619

First Name

Rosdiana

Last Name

Natzir

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Medicine, Hasanuddin University, Makassar 90245, Indonesia

Email

rosdianarnatzir@yahoo.com

City

-

Orcid

-

First Name

Subehan

Last Name

Subehan

MiddleName

-

Affiliation

Department of Pharmacognosy-Phytochemistry, Faculty of Pharmacy, Hasanuddin University, Makassar 90245, Indonesia

Email

subehan@unhas.ac.id

City

-

Orcid

-

First Name

Kyoko

Last Name

Goto

MiddleName

Nakagawa

Affiliation

School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-1192, Japan.

Email

kngoto@p.kanazawa-u.ac.jp

City

-

Orcid

0000-0002-1642-6538

First Name

Gemini

Last Name

Alam

MiddleName

-

Affiliation

Faculty of Pharmacy, Hasanuddin University Indonesia

Email

geminialam@unhas.ac.id

City

makassar

Orcid

0000-0003-3712-8457

Volume

65

Article Issue

3

Related Issue

29682

Issue Date

2022-03-01

Receive Date

2021-06-11

Publish Date

2022-03-01

Page Start

255

Page End

260

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 3_Pages 255-260.pdf

PDF . 523.4kB

Link

https://ejchem.journals.ekb.eg/article_197636.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=197636

Order

24

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Isolation and Characterization of Stigmasterol and β-sitosterol from Plectranthus scutellarioides var. color blaze dark star and Cytotoxicity of Its Fraction

Details

Type

Article

Created At

22 Jan 2023