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202307

Therapeutic Efficacy of Kumquat-Loaded Chitosan Nanoparticles against Toxoplasmosis in mice model

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Biochemistry

Abstract

The goal of this study was to compare the effects of kumquat extract and its chitosan nanoparticles on biochemical, histopathological, and parasitological factors in mice infected with Toxoplasma gondii versus spiramycin and control groups. A total of 35 mice, 7 of which were negative control and 28 was infected group, were used in the current study. All mice were sacrificed at 45 day after inoculation. Blood samples were collected. Then, sera Malondialdehyde (MDA), Catalase (CAT), Superoxide Dismutase 3 (SOD3), α-glutathione S-transferases (α-GST), and Interleukin 6 (IL-6) concentrations were measured using ELISA technique. In infected groups, CAT, SOD3, α-GST levels were decreased significantly (P

DOI

10.21608/ejchem.2021.100354.4663

Keywords

toxoplasma gondii, Oxidative Stress, kumquat, Chitosan nanoparticles

Authors

First Name

Wafaa

Last Name

Abd El-Hamed

MiddleName

-

Affiliation

a.Biological and Environmental Sciences Dept., Faculty of Home Economics, Al-Azhar University, Egypt

Email

memo_modern2010@yahoo.com

City

-

Orcid

-

First Name

Nahed

Last Name

Samy

MiddleName

-

Affiliation

bFood Science and Technology Dept., Faculty of Home Economics, Al-Azhar University, Egypt

Email

nahedsamy137@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Abd-Rabou

MiddleName

-

Affiliation

cHormones Department, Medical Research Division, and Stem Cell Laboratory, Center of Excellence for Advanced Science, National Research Centre, 12622, Giza, Egypt.

Email

ahmedchemia87@yahoo.com

City

-

Orcid

0000-0002-9875-7591

First Name

Zainab

Last Name

Salem

MiddleName

-

Affiliation

dNutrition and Food ScienceDept., Faculty of Home Economics, Al-Azhar University, Egypt.

Email

zainabsalem@yahoo.com

City

-

Orcid

-

Volume

65

Article Issue

2

Related Issue

28751

Issue Date

2022-02-01

Receive Date

2021-10-10

Publish Date

2022-02-01

Page Start

609

Page End

622

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 2_Pages 609-622.pdf

PDF . 954.9kB

Link

https://ejchem.journals.ekb.eg/article_202307.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=202307

Order

61

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023