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188621

Convenient Synthesis and Molecular Docking of Novel Pyrido [2,3- d ]pyrimidines as Potent Antimicrobial Candidates.

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

New 3-(3,4-dimethoxyphenyl)-1-(thiophene-2-yl)prop-2-en-1-one has been designed as a starting compound to synthesis a novel series of substituted pyrido[2,3-d]pyrimidine system incorporated to different Schiff's bases and enamine derivatives as potent antimicrobial compounds. Novel synthesized compounds were evaluated for their in-vitro antimicrobial potency against different gram-positive and gram-negative bacteria, where they reveal high effectuality at low concentration compared to Trimethoprim. Docking studies and structure-activity relationship declared that new pyrido [2,3-d] pyrimidines completely occupied the active pocket of Biotin Carboxylase of both bacterial types and fungal strains acting as selective Fatty Acid Synthesase type II inhibitors.

DOI

10.21608/ejchem.2021.87454.4223

Keywords

Pyrido [2, 3-d] pyrimidine, Antimicrobial, biotin carboxylase, Molecular docking

Authors

First Name

Alaadin

Last Name

sarhan

MiddleName

-

Affiliation

Therapeutic Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Center, 33 El Behouth St, Dokki-Giza, 12622-Egypt.

Email

dralaa1968@gmail.com

City

-

Orcid

0000-0001-5919-6536

First Name

hanaa

Last Name

soliman

MiddleName

M.

Affiliation

2Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo, Egypt, 12622.

Email

dr.hanaasol@hotmail.com

City

-

Orcid

0000-0003-0630-8682

First Name

Abdulrahman

Last Name

Saleh

MiddleName

M.

Affiliation

3 Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys) Al-Azhar University , Cairo-Egypt

Email

abdo.saleh240@azhar.edu.eg

City

-

Orcid

0000-0002-5153-7399

First Name

Zinab

Last Name

Nofal

MiddleName

M.

Affiliation

Therapeutic Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Center, 33 El Behouth St, Dokki-Giza, 12622-Egypt

Email

dr.zmnofal@yahoo.com

City

-

Orcid

-

Volume

65

Article Issue

2

Related Issue

28751

Issue Date

2022-02-01

Receive Date

2021-07-25

Publish Date

2022-02-01

Page Start

399

Page End

411

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 2_Pages 399-411.pdf

PDF . 1.0MB

Link

https://ejchem.journals.ekb.eg/article_188621.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=188621

Order

43

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023