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188234

Synthesis, modification, characterization, radiolabeling and in vivo behavior of carboxylated nanographene oxide sheets as a tumor imaging agent

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Nano chemistry

Abstract

Graphene is a crystalline form of carbon that is regarded as a novel and innovative product. carboxylated nanographene oxide sheets (NGO-COOH) was synthesized using a modified Hummer's method and assess their medical significance. NGO-COOH were successfully synthesized with an average size of 40 nm. FT-IR, UV–Vis, XPS spectrophotometry, and TEM were used to thoroughly describe them. The cytotoxicity function of NGO-COOH nanosheets were tested against cell line. The radiosynthesized [99mTc]Tc-NGO-COOH had a high radiolabeling yield (97.3±0.45 %). The tumor uptake of [99mTc]Tc-NGO-COOH nanosheets in an in vivo biodistribution model in tumor-bearing mice was high. NGO-COOH nanosheets may be a promising imaging agent, based on these findings.

DOI

10.21608/ejchem.2021.85086.4150

Keywords

Nanographene sheets, Technetium-99m, Nanosynthesis, Tumor imaging, Radiolabeling

Authors

First Name

Mohammed F. Elsabagh

Last Name

Elsabagh

MiddleName

-

Affiliation

Labeled Compounds Department, Hot Labs Center, Egyptian Atomic Energy Authority, Cairo 13759, Egypt.

Email

moh_pharma2008@yahoo.com

City

-

Orcid

-

First Name

Hend

Last Name

Fayez

MiddleName

-

Affiliation

Labeled Compounds Department, Hot Labs Center, Egyptian Atomic Energy Authority, Cairo 13759, Egypt.

Email

h_fayez88@yahoo.com

City

-

Orcid

-

First Name

Mohammed A.

Last Name

Motaleb

MiddleName

-

Affiliation

Labeled Compounds Department, Hot Labs Center, Egyptian Atomic Energy Authority, Cairo 13759, Egypt.

Email

mamotaleb@maktoob.com

City

-

Orcid

-

First Name

Wafaa A.

Last Name

Zaghary

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Cairo, Egypt.

Email

wzaghary7@gmail.com

City

-

Orcid

-

First Name

Tamer M.

Last Name

Sakr

MiddleName

-

Affiliation

Radioisotopes Production Facility, Second Egyptian Research Reactor Complex, Egyptian Atomic Energy Authority, Cairo 13759, Egypt.

Email

tamer_sakr78@yahoo.com

City

-

Orcid

-

Volume

65

Article Issue

2

Related Issue

28751

Issue Date

2022-02-01

Receive Date

2021-07-10

Publish Date

2022-02-01

Page Start

249

Page End

258

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 2_Pages 249-258.pdf

PDF . 560.8kB

Link

https://ejchem.journals.ekb.eg/article_188234.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=188234

Order

28

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Synthesis, modification, characterization, radiolabeling and in vivo behavior of carboxylated nanographene oxide sheets as a tumor imaging agent

Details

Type

Article

Created At

22 Jan 2023