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191804

Brain-Derived Neurotrophic Factor (BDNF) Levels In Relation To Depression In Egyptian Diabetic Women: A Pilot Study

Article

Last updated: 22 Jan 2023

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Subjects

-

Tags

Biochemistry

Abstract

Background: Brain-derived neurotrophic factor (BDNF) is a crucial moderator of neuronal plasticity in adults, a potential association between BDNF and depression has been reported. Besides BDNF plays a role in glucose and energy metabolism. Methods: This work included 180 women (25-55 years old). Ninety diabetic patients with the clinical diagnosis of depression and 90 were normal controls. Plasma BDNF was evaluated using ELISA. The Zung Self‑Rating Depression Scale (SDS) consisting of 20 objects with a Likert‑type scale after each was used. HbA1c were measured in each patient using a clinical auto-analyzer. Results: BDNF levels in serum decreased significantly in diabetic depressed women compared to controls. Moreover, BDNF levels were inversely proportional to age, BMI, HbAc1 and LDL.Conclusion: The study suggests that age, BMI, HbAc1 have a definite impact on the circulating levels of BDNF in peripheral blood. The outcomes delineate that BDNF could participate in glucose impairment and lipid metabolism in diabetic patients.

DOI

10.21608/ejchem.2021.83757.4108

Keywords

Brain-Derived Neurotrophic Factor (BDNF), BMI, depression, HbAc1, Lipid profile, Type 2 diabetes mellitus

Authors

First Name

Moushira

Last Name

Zaki

MiddleName

-

Affiliation

biological anthropology department, National Research Centre, Giza, Egypt.

Email

moushiraz@yahoo.com

City

Cairo

Orcid

-

First Name

Hala

Last Name

El-Bassyouni

MiddleName

-

Affiliation

Clinical Genetics Department, National Research Centre, Cairo, Egypt.

Email

halabassyouni@yahoo.com

City

-

Orcid

-

First Name

Mona Abd Elmotaleb A.

Last Name

Hussein

MiddleName

-

Affiliation

Internal Medicine National Institute of Diabetes and Endocrinology, Cairo, Egypt.

Email

lamonadr_2008@yahoo.com

City

-

Orcid

-

First Name

Hend M.

Last Name

Tawfeek

MiddleName

-

Affiliation

Internal Medicine Faculty of Medicine, Al-Azhar University- Girls.

Email

hendtawfeek@yahoo.com

City

-

Orcid

-

First Name

Mina Wassef

Last Name

Girgiss

MiddleName

-

Affiliation

Medical Department, Medical Research Division, National Research Centre, Giza, Egypt.

Email

mwgnicola@hotmail.com

City

cairo

Orcid

-

First Name

Magdi

Last Name

Ashour

MiddleName

-

Affiliation

Medical Biochemistry Department, Medical Research Division, National Research Centre, Giza, Egypt

Email

magdiashour2009@yahoo.com

City

-

Orcid

-

First Name

Eman

Last Name

Youness

MiddleName

-

Affiliation

Department of medical biochemistry National Research Centre, Giza, Egypt.

Email

hoctober2000@yahoo.com

City

-

Orcid

0000-0002-6492-1680

Volume

65

Article Issue

2

Related Issue

28751

Issue Date

2022-02-01

Receive Date

2021-07-03

Publish Date

2022-02-01

Page Start

175

Page End

179

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 2_Pages 175-179.pdf

PDF . 338.0kB

Link

https://ejchem.journals.ekb.eg/article_191804.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=191804

Order

20

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023