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191378

Smart Spectrophotometric Methods Based on Feasible Mathematical Processing and Classical Chemometry for The Simultaneous Assay of Alcaftadine and Ketorolac in Their Recently Appro

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Analytical chemistry

Abstract

Alcaftadine (ALC) and Ketorolac tromethamine (KET) binary combination is a new co-formulated pharmaceutical product that is used to treat allergic conjunctivitis. The present work utilizes three simple, precise, accurate, and rapid spectrophotometric and chemometric methods to determine the recently released pharmaceutical formulation. The methods include the first derivative of absorbance spectrum (Method A), dual-wavelength (Method B), and absorbance subtraction methods (Method C). ICH guidelines have been used to validate the developed methods. Linear regression lines were found over the concentration range of 1-9 and 1-12 μg mL-1, 1-8 and 2-10 μg mL-1, and 2-10 and 2-10 μg mL-1 of ALC and KET for methods A, B, and C respectively. All the methods showed correlation coefficients higher than 0.999, in addition to low LOQ and LOD which indicate high sensitivity of the proposed methods.

DOI

10.21608/ejchem.2021.82464.4098

Keywords

Alcaftadine, Ketorolac tromethamine, Spectrophotometric, chemometric, pharmaceutical formulation

Authors

First Name

Khaled

Last Name

Badr El-Din

MiddleName

-

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt

Email

kh.badr77@gmail.com

City

Minia

Orcid

-

First Name

Ahmed

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Sohag University, Sohag, Egypt

Email

ahmed.saad@pharm.sohag.edu.eg

City

-

Orcid

0000000263693989

First Name

Ahmed

Last Name

Khorshed

MiddleName

-

Affiliation

b Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Sohag University, Sohag, Egypt.

Email

ahmed_khorshed@pharm.sohag.edu.eg

City

-

Orcid

-

First Name

Sayed

Last Name

Derayea

MiddleName

-

Affiliation

Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt

Email

sayed.derayea@gmail.com

City

Minia

Orcid

0000-0001-5357-1761

First Name

Mohamed

Last Name

Oraby

MiddleName

-

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Sohag University, Sohag, Egypt

Email

moh-oraby@pharm.sohag.edu.eg

City

Sohag

Orcid

0000-0002-5965-7387

Volume

65

Article Issue

2

Related Issue

28751

Issue Date

2022-02-01

Receive Date

2021-07-01

Publish Date

2022-02-01

Page Start

167

Page End

174

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 65_Issue 2_Pages 167-174.pdf

PDF . 619.6kB

Link

https://ejchem.journals.ekb.eg/article_191378.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=191378

Order

19

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Smart Spectrophotometric Methods Based on Feasible Mathematical Processing and Classical Chemometry for The Simultaneous Assay of Alcaftadine and Ketorolac in Their Recently Approved Pharmaceutical Formulation.

Details

Type

Article

Created At

22 Jan 2023