Aim of the work: The aim of this study was to evaluate Vimentin, Fetuin-A, and lipoprotein(a) level in the sera of Acute myocardial Infarction (AMI) patients and to determine its relation with disease activity and severity. Patients and methods: Fifty one adult AMI patients (26 females and 27 males) and 41 healthy subjects (23 males and 18 females) matching age serving as the control group, were included in this study. Five milliliters of blood were collected from patients and controls, then centrifuged and the serum was separated and frozen as aliquots at -20 co until use. Measurement of the serum Vimentin, Fetuin-A, and lipoprotein(a) level in AMI patients and controls was done using the ELISA Kit. Results: Serum level of vimentin, and Lp(a)were significantly increased in AMI patient as compared to control group. Serum fetuin-A, albumin, and TP level in RA patient was significantly lower than control group. Hence present study concluded that vimentin, fetuin-A, and Lp(a) could be a useful marker for disease activity in AMI.