The study as a simple and rapid method has been described for determination of ketoprofen depending upon normal and first derivative IR Spectroscopy. The aim of this study is to develop a specific, precise and accurate spectroscopic methods that could be applied in quality control for the determination of ketoprofen in pharmaceutical formulations. Ketoprofen has been determined quantitatively in the range of (1000 to 4000)μg/ml depending on the measurement of transmittance for normal and its first derivative spectrum against the concentration with relative error+4.33% and 4.78% and RSD 1.15% and 1.37%, respectively. The values of r2of the both methods were 0.993 and 0.978, respectively. The methods have been applied for determination of ketoprofen in some pharmaceutical samples with recovery 97.691%.The obtained results were statistically compared to those of a reported HPLC technique and t-student's and F- tests at P=0.05 are calculated2SA1`