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181927

Spectrophotometric Estimation of Carvedilol via Schiff̕ s base Reaction with 4-Hydroxybenzaldehyde

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Analytical chemistry

Abstract

Simple, sensitive, precise, and accurate spectrophotometric method was suggested for the estimation of carvedilol (CARVL) as pure, and in it is formulation. The method is based on Schiff base reaction included condensation of CARVL with 4-hydroxybenzaldehyde(4-HBED) and 0.5 ml of concentrated sulphuric acid was added . All parameters that affected the formation of the product have been studied and the optimal was selected. The colored Schiff base product gave maximum absorption at 533 nm. The linearity of the method was obeyed Beer's law in the concentration range of 0.5 to 5 µg/ ml, with a molar absorptivity of 8.463 ×104 L mol-1 cm-1. The suggested method was applied to the determination of CARVL in Tablet formulations with accepted results of recovery of CARVL from it is drugs without any interfering of the common excipients.

DOI

10.21608/ejchem.2021.79131.3880

Keywords

Carvedilol, Schiff base, 4-hydroxybenzaldehyde, tablet formulations, Spectrophotometric determination

Authors

First Name

Ikhlass Th. S.

Last Name

Alallaf

MiddleName

-

Affiliation

Chemistry Department /.College of Science / University of Mosul / Mosul ,Iraq

Email

-

City

-

Orcid

-

First Name

Nabeel S.

Last Name

Othman

MiddleName

-

Affiliation

Chemistry Department /.College of Science / University of Mosul / Mosul ,Iraq

Email

nsn20002004@uomosul.edu.iq

City

-

Orcid

0000-0002-5930-3925

First Name

Amer Th.

Last Name

Al-Taee

MiddleName

-

Affiliation

Chemistry Department /.College of Science / University of Mosul / Mosul ,Iraq

Email

-

City

-

Orcid

-

Volume

65

Article Issue

1

Related Issue

28750

Issue Date

2022-01-01

Receive Date

2021-06-04

Publish Date

2022-01-01

Page Start

151

Page End

158

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_181927.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=181927

Order

17

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Spectrophotometric Estimation of Carvedilol via Schiff̕ s base Reaction with 4-Hydroxybenzaldehyde

Details

Type

Article

Created At

22 Jan 2023