Molecularly imprinted polymers (MIP) Showing high selectivity and affinity with an increasingly increasing analysis is now seen in the predetermined molecule (template) Furthermore, it is difficult to refine imprinted items due to the fact that there are multiple Variables to worry about, Any or all of this could have a likely effect on the chemical, Properties of the imprinted components in morphological and molecular identification, it is a rapidly emerging technique for the preparation of polymers having unique molecular recognition properties for a given compound MIP synthesis is a relatively easy and inexpensive process, either for its analogues or for a single enantiomer. For the selective extraction of COC and BE from urine samples, newly synthesized molecularly imprinted polymer sorbents were proposed in this report. using a functional monomer which To build a monolithic solid-phase micro extraction (SPME) fiber, Styrene and Allyl chloride are used, as well as Ethylene glycol methacrylate (EGDMA) as a suitable cross-linker and Cocaine as a template. A non-imprinted polymer was created by preparing a polymer without selective binding sites (NIP). All of these analytical procedures were utilized to extract, preconcentrate, and selectively determine Cocaine and its derivatives (SPME) with gas chromatography and mass spectrometry (GC/MS). sturdiness, The manufactured fiber's basic and vital role in SPME is due to its stability and durability. The samples were taken from a suspected cocaine abuser who was donated by the medico-legal directorate (Baghdad, Iraq). The analytes were monitored using a (GC MS), UV-vis, Scanning electron microscopy (SEM), and FTIR. The relative standard deviations (RSD percent ) for two patients' repeated studies for three measurements vary from (1.587-4.545) percent (at 20-100 ppm of Cocaine). Cocaine relative recoveries in human urine samples spiked with the drug are in the range of (102-105).